NDLI: Digital gene expression profiling (DGE) of cadmium-treated Drosophila melanogaster.

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Digital gene expression profiling (DGE) of cadmium-treated Drosophila melanogaster.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guan, Delong Mo, Fei Han, Yan Gu, Wei Zhang, Min
Description	Country affiliation: China Author Affiliation: Guan D ( College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China.); Mo F ( College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China.); Han Y ( College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China.); Gu W ( College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China.); Zhang M ( College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China. Electronic address: zhangmin451@snnu.edu.cn.)
Abstract	Cadmium is highly toxic and can cause oxidative damage, metabolic disorders, and reduced lifespan and fertility in animals. In this study, we investigated the effects of cadmium in Drosophila melanogaster, performing transcriptome analysis by using tag-based digital gene expression (DGE) profiling. Among 1970 candidate genes, 1443 were up-regulated and 527 were down-regulated following cadmium exposure. Using Gene Ontology analysis, we found that cadmium stress affects three processes: transferase activity, stress response, and the cell cycle. Furthermore, we identified five differentially expressed genes (confirmed by real-time PCR) involved in all three processes: Ald, Cdc2, skpA, tefu, and Pvr. Pathway analysis revealed that these genes were involved in the cell cycle pathway and fat digestion and absorption pathway. This study reveals the gene expression response to cadmium stress in Drosophila, it provides insights into the mechanisms of this response, and it could contribute to our understanding of cadmium toxicity in humans.
File Format	HTM / HTML
ISSN	13826689
Issue Number	1
Volume Number	39
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2015-01-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Cadmium Toxicity Drosophila Melanogaster Drug Effects Animals Cdc2 Protein Kinase Genetics Cell Cycle Cell Cycle Proteins Drosophila Proteins Female Gene Expression Profiling Gene Ontology Protein-serine-threonine Kinases Receptor Protein-tyrosine Kinases Skp Cullin F-box Protein Ligases Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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