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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Abdel Moneim, Ahmed E. El-Khadragy, Manal F. |
| Description | Country affiliation: Spain Author Affiliation: Abdel Moneim AE ( Biomedical Research Center, University of Granada, Granada, Spain. aest1977@hotmail.com) |
| Abstract | The purpose of this study was to evaluate the effect of pomegranate (Punica granatum) in inhibiting and reversing the nephrotoxicity of carbon tetrachloride, a potent oxidative stress inducer which induces cellular kidney damage. Rats were intraperitoneally injected with carbon tetrachloride (2 mL/kg body weight) which produced severe renal tissue damage, as demonstrated by decreased uric acid and dramatic elevation of urea and creatinine. In addition, carbon tetrachloride injection caused oxidative stress in rats, as evidenced by increased lipid peroxidation and nitrite/nitrate (NO x ) concentrations in the renal tissue, along with a remarkable reduction in superoxide dismutase, catalase, glutathione transferase, glutathione reductase, glutathione peroxidase activities and glutathione content. We suggested that pomegranate juice was able to elevate the antioxidant defense system, clean up free radicals, lessen oxidative damages and protect the kidney against carbon tetrachloride-induced toxicity, thus having a potential protective effect. |
| File Format | HTM / HTML |
| ISSN | 11387548 |
| Issue Number | 3 |
| Volume Number | 69 |
| e-ISSN | 18778755 |
| Journal | Journal of Physiology and Biochemistry |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2013-09-01 |
| Publisher Place | Spain |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Physiology Discipline Biochemistry Acute Kidney Injury Drug Therapy Antioxidants Pharmacology Beverages Kidney Drug Effects Plant Extracts Protective Agents Punicaceae Chemistry Chemically Induced Metabolism Pathology Animals Carbon Tetrachloride Catalase Creatinine Blood Glutathione Glutathione Peroxidase Glutathione Reductase Glutathione Transferase Lipid Peroxidation Male Oxidative Stress Rats Rats, Wistar Superoxide Dismutase Urea Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Medicine Biochemistry |
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