NDLI: Influence of the carbamate fungicide benomyl on the gene expression and activity of aromatase in the human breast carcinoma cell line MCF-7.

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Influence of the carbamate fungicide benomyl on the gene expression and activity of aromatase in the human breast carcinoma cell line MCF-7.

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Influence of the carbamate fungicide benomyl on the gene expression and activity of aromatase in the human breast carcinoma cell line MCF-7.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kawaratani, Yasuyuki Matsuoka, Takeshi Hirata, Yoshiyuki Fukata, Naofumi Nagaoka, Yasuo Uesato, Shinichi
Description	Author Affiliation: Kawaratani Y ( Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan. Electronic address: hoechst.atanpe@gmail.com.); Matsuoka T ( Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan. Electronic address: audaciapaula@gmail.com.); Hirata Y ( Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan. Electronic address: y.hirata@gly.oups.ac.jp.); Fukata N ( Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan. Electronic address: fukanao0921@gmail.com.); Nagaoka Y ( Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan. Electronic address: ynagaoka@kansai-u.ac.jp.); Uesato S ( Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan. Electronic address: uesato@kansai-u.ac.jp.)
Abstract	The carbamate fungicide benomyl reportedly inhibited the growth of the human breast cancer cell line MCF-7 by inducing apoptosis. However, influence of benomyl on the expression and activity of aromatase of MCF-7 cells remains to be examined, since benomyl was identified as an endocrine disruptor. We here confirmed through cell cycle analysis and immunofluorescence staining that benomyl damaged microtubules and caused apoptosis. We also found that benomyl inhibited histone deacetylase (HDAC) 1 and accumulated acetylated histone H3 in MCF-7 cells. Additionally, benomyl enhanced the levels of aromatase protein and mRNA, albeit at high concentrations. It is thus likely that benomyl enhanced the promoter activity of the aromatase gene via acetylation of histone H3 as does the HDAC inhibitor Vorinostat. In conclusion, benomyl remains to be a risk factor as an endocrine disruptor for breast cancer.
File Format	HTM / HTML
ISSN	13826689
Issue Number	1
Volume Number	39
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2015-01-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Aromatase Genetics Metabolism Benomyl Toxicity Fungicides, Industrial Gene Expression Regulation, Enzymologic Drug Effects Histone Deacetylase Inhibitors Breast Neoplasms Enzymology Histone Deacetylase 1 Antagonists & Inhibitors Histones Humans Mcf-7 Cells Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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