NDLI: Dieckol as a novel anti-proliferative and anti-angiogenic agent and computational anti-angiogenic activity evaluation.

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Dieckol as a novel anti-proliferative and anti-angiogenic agent and computational anti-angiogenic activity evaluation.

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Dieckol as a novel anti-proliferative and anti-angiogenic agent and computational anti-angiogenic activity evaluation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Yong-Xin Li, Yong Je, Jae-Young Kim, Se-Kwon
Description	Author Affiliation: Li YX ( Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea.); Li Y ( School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, 1035, Boshuo Road, Jing Yue Economic Development Zone, Chanchun City, Jilin Province, People's Republic of China.); Je JY ( Specialized Graduate School Science and Technology Convergence, Department of Marine Bio Convergence Science, Pukyong National University, Busan 608-737, Republic of Korea.); Kim SK ( Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea)
Abstract	In the current study it was found that dieckol isolated from edible brown algae, Ecklonia cava (EC), as potent anti-proliferative and anti-angiogenic agent. Vascular endothelial growth factor (VEGF) induced EA.hy926 cell proliferation was suppressed by dieckol treatment. Further, it showed a significant inhibition of cell migration via inhibiting the protein and gene expression levels of matrix metalloproteinases, MMP-2 and -9. The signaling cascade underlying these responses was found as the dieckol induced inhibition of mitogen-activated protein kinase (MAPK) signaling pathway molecules, ERK and p38. Docking calculations were carried out on AP-N, VEGFR-1, MMP-2, MMP-9, Akt and Erk2 proteins model. Collectively, these results demonstrate the effective anti-proliferative and anti-migratory activity of dieckol on VEGF induced EA.hy926 through MAPK molecular signaling pathways which could be effectively correlated to its potential as an anti-angiogenic candidate. Therefore, this study reveals the potential of dieckol to be used in the design of anti-angiogenic agents.
File Format	HTM / HTML
ISSN	13826689
Issue Number	1
Volume Number	39
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2015-01-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Angiogenesis Inhibitors Pharmacology Benzofurans Antigens, Cd13 Antagonists & Inhibitors Metabolism Cell Line Cell Movement Drug Effects Cell Proliferation Cell Survival Humans Map Kinase Signaling System Matrix Metalloproteinase 2 Genetics Matrix Metalloproteinase 9 Mitogen-activated Protein Kinases Molecular Docking Simulation Phaeophyta Proto-oncogene Proteins C-akt Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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