NDLI: RNA-seq based on transcriptome reveals differ genetic expressing in Chlamys farreri exposed to carcinogen PAHs.

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RNA-seq based on transcriptome reveals differ genetic expressing in Chlamys farreri exposed to carcinogen PAHs.

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RNA-seq based on transcriptome reveals differ genetic expressing in Chlamys farreri exposed to carcinogen PAHs.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jin, Qian Pan, Luqing Liu, Tong Hu, Fengxiao
Description	Author Affiliation: Jin Q ( Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China.); Pan L ( Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China. Electronic address: panlq@ouc.edu.cn.); Liu T ( Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China.); Hu F ( Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China.)
Abstract	The effects of a mixture of carcinogen polycyclic aromatic hydrocarbons (BaP, BaA, BbF and CHR) on transcriptional responses in the digestive gland of scallop, Chlamys farreri, were investigated by high-throughput RNA-sequencing (RNA-seq) technologies. In total, 209 and 260 genes were identified as significantly up- or down-regulated, respectively. Functional analysis based on gene ontology (GO) classification system and the Kyoto encyclopedia of genes and genomes (KEGG) database revealed that PAHs significantly altered the expression of genes involved in stress response, detoxication, antioxidation which were extensively discussed. In particular, CYP450 2P1 and QO mRNA expression were found to be up-regulated by exposure to PAHs mixture, suggesting that CYP450 2P1 and QO mRNA expression can be a potential marker for prediction of the biological effects of a mixture of PAHs on scallops.
File Format	HTM / HTML
ISSN	13826689
Issue Number	1
Volume Number	39
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2015-01-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Carcinogens Toxicity Pectinidae Drug Effects Polycyclic Hydrocarbons, Aromatic Animals Cytochrome P-450 Enzyme System Genetics Gene Expression Profiling Hsp70 Heat-shock Proteins Rna, Messenger Metabolism Sequence Analysis, Rna Transcriptome Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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