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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cesur, Gokhan Doguc, Duygu Kumbul Yildiz, Mustafa Ogut, Serdal Polat, Mumin Ongel, Kurtulus |
| Description | Country affiliation: Turkey Author Affiliation: Cesur G ( 1Department of Physiology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.) |
| Abstract | Nuclear medicine has been using radiopharmaceuticals for the diagnostic and therapeutic purposes of many diseases. Technetium-(99m) methoxyisobutylisonitrile ((99m)Tc sestamibi) is a lypophilic complex that has a positive-loaded isonitril group. Aim of the study is to investigate whether (99m)Tc sestamibi, which is one of the mostly used radiopharmaceuticals in nuclear medicine field, causes oxidative damage or not in rats' heart after an injection. A total of 16 male Sprague Dawley rats were randomly divided into two groups: group I: (99m)Tc sestamibi group, (99m)Tc sestamibi administered intravenously with the dose of 25MBq; group II: control group, one dose of isotonic sodium chloride was administered intravenous with the same volume as (99m)Tc sestamibi group. Malondialdehyde (MDA) and total oxidant status (TOS) were used as markers of oxidative stress-induced heart impairment. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and total antioxidant status (TAS) activities were studied to evaluate the changes in the antioxidant status. In the (99m)Tc sestamibi group (group I), animals treated with (99m)Tc sestamibi produced a significant decrease in the activities of antioxidant enzymes (SOD and CAT), while MDA level increased when compared with control group (group II) in myocardial tissue (p < 0.05). On the other hand, the GSH-Px activities were significantly increased in the (99m)Tc sestamibi-treated rats compared with the untreated rats (p < 0.05). There was no significant difference in the TAS and TOS levels of plasma. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 2 |
| Volume Number | 30 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2014-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Antioxidants Metabolism Heart Drug Effects Lipid Peroxidation Radiopharmaceuticals Adverse Effects Technetium Tc 99m Sestamibi Animals Catalase Blood Dose-response Relationship, Drug Glutathione Peroxidase Physiology Male Malondialdehyde Myocardium Pathology Rats Rats, Sprague-dawley Superoxide Dismutase Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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