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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Sen Wang, Haibo Su, Mingzhi Hwang, Gwi Ja Hong, Jongki Jung, Jee H. |
| Description | Author Affiliation: Liu S ( a College of Pharmacy , Pusan National University , Busan , Republic of Korea.); Wang H ( a College of Pharmacy , Pusan National University , Busan , Republic of Korea.); Su M ( a College of Pharmacy , Pusan National University , Busan , Republic of Korea.); Hwang GJ ( a College of Pharmacy , Pusan National University , Busan , Republic of Korea.); Hong J ( b College of Pharmacy , Kyung Hee University , Seoul , Republic of Korea.); Jung JH ( a College of Pharmacy , Pusan National University , Busan , Republic of Korea.) |
| Abstract | Two new metabolites, diorcinolic acid (1) and ß-d-glucopyranosyl aspergillusene A (8), together with six diphenylethers (2-7), a diketopiperazine (9), a chromone (10) and a xanthone (11) were isolated from the fungus Aspergillus sydowii derived from the marine sponge Stelletta sp. The planar structures and their relative configurations were elucidated by analysing 1D, 2D NMR and HRESIMS data. Compound 8 is the first glycoside of phenolic bisabolane sesquiterpenes. Compounds 1 and 8 exhibited mild cytotoxicity against KB (human nasopharyngeal carcinoma cells), HepG2 (human liver cancer cells) and HCT 116 (human colon cancer cells). All compounds were evaluated for antibacterial activity and their abilities to suppress LPS-induced nitric oxide (NO) production. Compounds 2 and 4-7 showed mild antibacterial activity against human pathogen Staphylococcus aureus and fish pathogens Streptococcus iniae and Vibrio ichthyoenteri, and compounds 4 and 7 weakly suppressed NO production. |
| File Format | HTM / HTML |
| ISSN | 14786419 |
| Journal | Natural Product Research |
| e-ISSN | 14786427 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2017-02-13 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Natural Products |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Plant Science Analytical Chemistry Biochemistry |
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