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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Uchoa, Paula Karina S. Pimenta, Antonia T. A. Braz-Filho, Raimundo de Oliveira, Maria da Conceição F. Saraiva, Natália N. Rodrigues, Barbara S. F. Pfenning, Ludwig H. Abreu, Lucas M. Wilke, Diego V. Florêncio, Katharine G. D. Lima, Mary Anne S. |
| Description | Country affiliation: Brazil Author Affiliation: Uchoa PK ( a Departamento de Química Orgânica e Inorgânica, Centro de Ciências , Universidade Federal do Ceará , Fortaleza , Brasil.); Pimenta AT ( a Departamento de Química Orgânica e Inorgânica, Centro de Ciências , Universidade Federal do Ceará , Fortaleza , Brasil.); Braz-Filho R ( b Laboratório de Ciências Químicas , Universidade Estadual do Norte Fluminense Darcy Ribeiro, FAPERJ , Campos dos Goytacazes , Brasil.); de Oliveira MD ( c Departamento de Química , Universidade Federal Rural do Rio de Janeiro , Seropédica-RJ , Brasil.); Saraiva NN ( a Departamento de Química Orgânica e Inorgânica, Centro de Ciências , Universidade Federal do Ceará , Fortaleza , Brasil.); Rodrigues BS ( d Departamento de Farmácia , Universidade Federal de Sergipe , Lagarto , Brasil.); Pfenning LH ( e Departamento de Ensino , Instituto Federal de Educação Ciência e Tecnologia do Ceará - Campus Canindé , Canindé , Brasil.); Abreu LM ( f Departamento de Fitopatologia , Universidade Federal de Lavras , Lavras , Brasil.); Wilke DV ( f Departamento de Fitopatologia , Universidade Federal de Lavras , Lavras , Brasil.); Florêncio KG ( g Núcleo de Pesquisa de Desenvolvimento de Medicamentos, Departamento de Farmacologia e Fisiologia , Centro de Ciências da Saúde , Universidade Federal do Ceará , Fortaleza , Brasil.); Lima MA ( g Núcleo de Pesquisa de Desenvolvimento de Medicamentos, Departamento de Farmacologia e Fisiologia , Centro de Ciências da Saúde , Universidade Federal do Ceará , Fortaleza , Brasil.) |
| Abstract | A fungal strain of Aspergillus niger was recovered from sediments collected in the Northeast coast of Brazil (Pecém's offshore port terminal). Cultivation in different growth media yielded a new ester furan derivative, 1, along with malformin A1, malformin C, cyclo (trans-4-hydroxy-L-Pro-L-Leu), cyclo (trans-4-hydroxy-L-Pro-L-Phe), cyclo (L-Pro-L-Leu), cyclo (L-Pro-L-Phe), pseurotin D, pseurotin A, chlovalicin, cyclo (L-Pro-L-Tyr) and cyclo (L-Pro-L-Val). Compound 1 was cytotoxic against HCT-116 cell line, showing IC = 2.9 µg/mL (CI 95% from 1.8 to 4.7 µg/mL). |
| File Format | HTM / HTML |
| ISSN | 14786419 |
| Journal | Natural Product Research |
| e-ISSN | 14786427 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2017-01-30 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Natural Products |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Plant Science Analytical Chemistry Biochemistry |
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