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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tribuiani, Natália Tavares, Marylu Oliveira Santana, Monique Neves Fontana Oliveira, Isadora Caruso Amaral Filho, Jorge do Silva, Magali Glauzer Dos Santos, Marcio Galdino Cogo, José Carlos Floriano, Rafael Stuani Cogo-Müller, Karina Oshima-Franco, Yoko |
| Description | Country affiliation: Brazil Author Affiliation: Tribuiani N ( a Post-Graduate Program in Pharmaceutical Sciences and Pharmacy Graduate Course , University of Sorocaba, (UNISO) , Sorocaba , Brazil.); Tavares MO ( a Post-Graduate Program in Pharmaceutical Sciences and Pharmacy Graduate Course , University of Sorocaba, (UNISO) , Sorocaba , Brazil.); Santana MN ( a Post-Graduate Program in Pharmaceutical Sciences and Pharmacy Graduate Course , University of Sorocaba, (UNISO) , Sorocaba , Brazil.); Fontana Oliveira IC ( a Post-Graduate Program in Pharmaceutical Sciences and Pharmacy Graduate Course , University of Sorocaba, (UNISO) , Sorocaba , Brazil.); Amaral Filho JD ( a Post-Graduate Program in Pharmaceutical Sciences and Pharmacy Graduate Course , University of Sorocaba, (UNISO) , Sorocaba , Brazil.); Silva MG ( a Post-Graduate Program in Pharmaceutical Sciences and Pharmacy Graduate Course , University of Sorocaba, (UNISO) , Sorocaba , Brazil.); Dos Santos MG ( b Environmental Sciences Post-Graduate Program, (PGCiamb) , Tocantins Federal University (UFT) , Palmas , Brazil.); Cogo JC ( c Post-Graduate Program in Biomedical Engineering and Bioengeneering , University Camilo Castelo Branco (Unicastelo) , Descalvado , Brazil.); Floriano RS ( d Faculty of Medical Sciences, Department of Pharmacology , State University of Campinas (UNICAMP) , Campinas , Brazil.); Cogo-Müller K ( e Faculty of Pharmaceutical Sciences , State University of Campinas (UNICAMP) , Campinas , Brazil.); Oshima-Franco Y ( a Post-Graduate Program in Pharmaceutical Sciences and Pharmacy Graduate Course , University of Sorocaba, (UNISO) , Sorocaba , Brazil.) |
| Abstract | The ability of Terminalia fagifolia hydroalcoholic extract (Tf-HE) to neutralise the paralysis and myotoxicity induced by Bothrops jararacussu venom was assayed using mouse phrenic nerve-diaphragm (PND) preparation and two varieties of chick biventer cervicis (BC) preparations. Tf-HE 100 µg/mL and 500 µg/mL were tested against 40 and 200 µg of venom/mL in PND and BC preparations, respectively, using pre- and post-venom incubation treatments. The effects of Tf-HE against the myotoxicity caused by venom were evaluated via histological analysis (PND) and creatine kinase (CK) release (BC). Tf-HE was able to reverse the venom paralysis in both preparation types. The contractures to exogenous ACh in BC preparations showed that Tf-HE may act on extrinsic, preserving those intrinsic postsynaptic receptors. There was a positive correlation between CK and morphological changes. The high non-hemolytic saponin content can explain the Tf-HE efficacy against the toxic effects of B. jararacussu venom in vertebrate neuromuscular preparations. |
| File Format | HTM / HTML |
| ISSN | 14786419 |
| Journal | Natural Product Research |
| e-ISSN | 14786427 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2017-03-02 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Natural Products |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Plant Science Analytical Chemistry Biochemistry |
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