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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rajapriya, Sadanandan Geetha, Arumugam Ganesan Kripa, Kavasseri |
| Description | Country affiliation: India Author Affiliation: Rajapriya S ( a Department of Biochemistry Bharathi Women's College (Affiliated to University of Madras) , Chennai , Tamil Nadu , India.); Geetha A ( a Department of Biochemistry Bharathi Women's College (Affiliated to University of Madras) , Chennai , Tamil Nadu , India.); Ganesan Kripa K ( b Department of Biochemistry, School of Life Sciences , Vels University , Chennai , Tamil Nadu , India.) |
| Abstract | The ever-increasing problem of pancreatitis due to alcohol abuse demands evaluation of novel drugs of plant origin. This study explores the therapeutic effects of the methanolic extract of Brassica oleraceae (MEBO) on ethanol and cerulein induced pancreatitis in rats. The MEBO was subjected to GC-MS and HPLC analysis. Male albino Wistar rats were divided into various groups, fed with alcohol (36% of total calories for 5 weeks) and cerulein (20 µg/kg b.wt i.p, weekly thrice for last three weeks) with or without MEBO (40 mg/kg b.wt). Serum lipase, amylase, IL-1ß, IL-18, caspase-1, lipid peroxides, oxidative stress index and antioxidant status were assessed in pancreas. Six compounds were identified in GC-MS analysis. Co-administration of MEBO reduced the pancreatic marker enzymes in serum, IL-1ß, IL-18 and caspase-1 and increased the antioxidant status of pancreas. The pancreato-protective effect of Brassica oleraceae may be attributed to well-known anti-inflammatory flavonoids, luteolin, quercetin and myricetin. |
| File Format | HTM / HTML |
| ISSN | 14786419 |
| Journal | Natural Product Research |
| e-ISSN | 14786427 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2017-01-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Natural Products |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Plant Science Analytical Chemistry Biochemistry |
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