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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Anwar, Sirajudheen Crouch, Rebecca A. Awadh Ali, Nasser A. Al-Fatimi, Mohamed A. Setzer, William N. Wessjohann, Ludger |
| Description | Author Affiliation: Anwar S ( a Department of Medicinal Chemistry , College of Clinical Pharmacy, Albaha University , Albaha , KSA.); Crouch RA ( b Department of Chemistry , University of Alabama in Huntsville , Huntsville , AL , USA.); Awadh Ali NA ( c Department of Pharmacognosy , College of Clinical Pharmacy, Albaha University , Albaha , KSA.); Al-Fatimi MA ( d Pharmacognosy Department, Faculty of Pharmacy , Aden University , Aden , Yemen.); Setzer WN ( b Department of Chemistry , University of Alabama in Huntsville , Huntsville , AL , USA.); Wessjohann L ( e Department of Bio-organic Chemistry , Leibniz Institute of Plant Biochemistry , Halle/Saale , Germany.) |
| Abstract | The hydrodistilled essential oil obtained from the dried leaves of Myrtus communis, collected in Yemen, was analysed by GC-MS. Forty-one compounds were identified, representing 96.3% of the total oil. The major constituents of essential oil were oxygenated monoterpenoids (87.1%), linalool (29.1%), 1,8-cineole (18.4%), -terpineol (10.8%), geraniol (7.3%) and linalyl acetate (7.4%). The essential oil was assessed for its antimicrobial activity using a disc diffusion assay and resulted in moderate to potent antibacterial and antifungal activities targeting mainly Bacillus subtilis, Staphylococcus aureus and Candida albicans. The oil moderately reduced the diphenylpicrylhydrazyl radical (IC = 4.2 µL/mL or 4.1 mg/mL). In vitro cytotoxicity evaluation against HT29 (human colonic adenocarcinoma cells) showed that the essential oil exhibited a moderate antitumor effect with IC of 110 ± 4 µg/mL. Hierarchical cluster analysis of M. communis has been carried out based on the chemical compositions of 99 samples reported in the literature, including Yemeni sample. |
| File Format | HTM / HTML |
| ISSN | 14786419 |
| Journal | Natural Product Research |
| e-ISSN | 14786427 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2017-01-09 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Natural Products |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Plant Science Analytical Chemistry Biochemistry |
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