NDLI: Role of transcription factors in small intestinal ischemia-reperfusion injury and tolerance induced by ischemic preconditioning.

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Immunologic aspects and rejection in solid organ versus reconstructive transplantation.

Chagas' disease and solid organ transplantation.

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Stem cell factor, interleukin-16, and interleukin-2 receptor alpha are predictive biomarkers for delayed and slow graft function.

Role of transcription factors in small intestinal ischemia-reperfusion injury and tolerance induced by ischemic preconditioning.

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Liver injury following renal ischemia reperfusion in rats.

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Clinical outcome of preemptive kidney transplantation in patients with diabetes mellitus.

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Low-dose calcineurin inhibitor regimen combined with mammalian target of rapamycin inhibitors preserves kidney functions in renal transplant recipients without allograft nephropathy.

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Loss of bone mineral density in renal transplantation recipients.

Cinacalcet improves bone density in post-kidney transplant hyperparathyroidism.

Tumor necrosis factor alpha promoter polymorphism in posttransplantation diabetes mellitus of renal transplant recipients.

Hyperuricemia in kidney transplant recipients with intact graft function.

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Standard formula for liver volume in Middle Eastern Arabic adults.

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Intraoperative changes in hyponatremia as a risk factor for prolonged mechanical ventilation after living donor liver transplantation.

Factors influencing the concentration of cytokines during liver transplantation.

Does model for end-stage liver disease score predict the short-term outcome of living donor liver transplantation?

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Strong impact of acute kidney injury on survival after liver transplantation.

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Chronic kidney disease following liver transplantation: a South Australian experience.

Factors associated with sustained virological response in liver transplant recipients with recurrent hepatitis C.

Delayed kidney allograft function after simultaneous pancreas-kidney transplantation.

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Serum midkine is related to NYHA class and cystatin C in heart transplant recipients.

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Lung transplantation in cystic fibrosis patients in the Czech Republic: initial single-center experience.

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Hematuria due to adenoviral infection in bone marrow transplant recipients.

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Human umbilical cord blood-derived stromal cells: a new resource in hematopoietic reconstitution in mouse haploidentical transplantation.

Adult endothelial progenitor cells retain hematopoiesis potential.

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Immune suppression produced by intrathymic inoculation with xenogeneic antigen and whole-body Î³-irradiation in a pig-to-monkey heart transplantation model.

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Human hepatoma HepaRG cell line engraftment in severe combined immunodeficient × beige mice using mouse-specific anti-Fas antibody.

Effects and mechanisms of tacrolimus on development of murine Th17 cells.

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Recurrent non-melanoma skin cancer: remission of field cancerization after conversion from calcineurin inhibitor- to proliferation signal inhibitor-based immunosuppression in a cardiac transplant recipient.

Aerosolized tacrolimus: a case report in a lung transplant recipient.

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A lucky fall? Case report.

Simultaneous pancreas-kidney transplantation in HIV-infected patients: a case report and literature review.

Late-onset intestinal perforation in the setting of posttransplantation microangiopathy: a case report.

Treatment of acute graft-vs-host disease after simultaneous pancreas-kidney transplantation: a case report.

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Role of transcription factors in small intestinal ischemia-reperfusion injury and tolerance induced by ischemic preconditioning.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Takeshita, M. Tani, T. Harada, S. Hayashi, H. Itoh, H. Tajima, H. Ohnishi, I. Takamura, H. Fushida, S. Kayahara, M.
Description	Country affiliation: Japan Author Affiliation: Takeshita M ( Department of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan.)
Abstract	BACKGROUND: Small intestinal ischemia-reperfusion (I/R) injury, a clinically important condition, induces severe organ damage. Ischemic preconditioning (IPC) produces tolerance to long-term I/R by inducing a short-term I/R. Herein, we have examined the reduction in the extent of injury by IPC. METHODS: Small intestinal I/R injury was induced in rats by clamping the superior mesenteric artery (SMA) for 30 minutes followed by reperfusion for various 30 minutes. The IPC + I/R group underwent a short-term I/R (IPC) prior to long-term I/R. Nuclear factor-κB (NF-κB) activity was analyzed by an electrophoretic mobility shift assay and cytokine mRNA levels, by reverse transcription-polymerase chain reaction. Apoptosis-related genes were analyzed by Western blotting and immunohistochemistry, and apoptotic cells, by TUNEL staining. RESULTS: The animals were subjected to 30 minutes of ischemia followed by 30 minutes of reperfusion. NF-κB activity increased in the I/R group and decreased in the IPC + I/R group. The IPC + I/R group showed decreased cytokine in mRNA levels. Expression of the proapoptotic gene caspase-3 was increased in the I/R and decreased in the IPC + I/R group. Expression of the antiapoptotic gene Bcl-xL was increased in the IPC + I/R group. The number of apoptotic cells was increased in the I/R and decreased in the IPC + I/R group. CONCLUSION: Small intestinal I/R injury was reduced by IPC produced by clamping the SMA; thus, IPC may have potential clinical applications in the future.
File Format	HTM / HTML
ISSN	00411345
Issue Number	9
Volume Number	42
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2010-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Ischemic Preconditioning Jejunum Blood Supply Metabolism Nf-kappa B Reperfusion Injury Prevention & Control Animals Apoptosis Binding Sites Blotting, Western Caspase 3 Constriction Dna Disease Models, Animal Electrophoretic Mobility Shift Assay Gene Expression Regulation Immunohistochemistry In Situ Nick-end Labeling Intercellular Adhesion Molecule-1 Genetics Interleukin-1beta Pathology Male Mesenteric Artery, Superior Surgery Rna, Messenger Rats Rats, Inbred Lew Reverse Transcriptase Polymerase Chain Reaction Time Factors Tumor Necrosis Factor-alpha Bcl-x Protein Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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