NDLI: Effect of necrosis modulator necrox-7 on hepatic ischemia-reperfusion injury in beagle dogs.

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Effect of necrosis modulator necrox-7 on hepatic ischemia-reperfusion injury in beagle dogs.

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Effect of necrosis modulator necrox-7 on hepatic ischemia-reperfusion injury in beagle dogs.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Choi, J. M. Park, K. M. Kim, S. H. Hwang, D. W. Chon, S. H. Lee, J. H. Lee, S. Y. Lee, Y. J.
Description	Author Affiliation: Choi JM ( Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.)
Abstract	OBJECTIVE: The liver is susceptible to ischemia-reperfusion (IR) injury during inflow occlusion for hepatectomy. There is no effective pharmacologic agent available to prevent the release of high-mobility-group box 1 (HMGB1) or to ameliorate IR injury. This pilot study sought to develop a model in beagle dogs for the purpose of testing the efficacy of a necrosis modulator, necrox-7, to prevent hepatic IR injury in beagle dogs. METHODS: Six male beagle dogs were randomly assigned to the control group (group A; n = 3) or the treatment group (group B; n = 3). Under general anesthesia, group B received intravenous infusion of necrox-7 (13 mg/kg over 20 minutes) followed by 60 minutes of left hepatic inflow occlusion and 60 minutes of reperfusion. Both groups were tested for serum biochemicals, hematology values, liver biopsies, and plasma HMGB1 levels over a 48-hour period. RESULTS: The maximum alanine transferase (ALT), aspartate transferase (AST), and lactate dehydrogenase (LDH) levels among group A versus group B were: ALT 868.3 ± 337.4 IU/L vs 274.3 ± 72.6 IU/L (P = .041); AST 1,024.7 ± 246.5 IU/L vs 505.3 ± 66.7 IU/L (P = .024); and LDH 962.7 ± 226.2 IU/L vs 552.7 ± 62.4 IU/L (P = .039). Liver biopsy demonstrated marked necrosis and inflammatory infiltrates in group A, whereas group B showed little evidence of IR injury. The plasma HMGB1 concentration was significantly lower among group B versus A. CONCLUSION: This pilot study developed a hepatic IR injury model, demonstrating that necrox-7 reduced hepatic necrosis secondary to IR injury in a large animal setting.
File Format	HTM / HTML
ISSN	00411345
Issue Number	9
Volume Number	42
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2010-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Liver Blood Supply Drug Effects Organic Chemicals Pharmacology Protective Agents Reperfusion Injury Prevention & Control Alanine Transaminase Blood Animals Aspartate Aminotransferases Biological Markers Biopsy Disease Models, Animal Dogs Hmgb1 Protein Infusions, Intravenous L-lactate Dehydrogenase Metabolism Pathology Male Necrosis Administration & Dosage Pilot Projects Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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