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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bacchi, G. Buscaroli, A. Fusari, M. Neri, L. Cappuccilli, M. L. Carretta, E. Stefoni, S. |
| Spatial Coverage | Italy |
| Description | Country affiliation: Italy Author Affiliation: Bacchi G ( Department of Internal Medicine, Aging and Renal Disease, University of Bologna, Bologna, Italy. giuliana.bacchi@unibo.it) |
| Abstract | INTRODUCTION: Delayed graft function (DGF) is a common complication in kidney transplantation. We sought to evaluate possible correlates for DGF including intraoperative parameters, focusing on fluid replacement and central venous pressure (CVP) values among patients undergoing kidney transplantation at our center. METHODS: One hundred fifty-five cadaveric donor transplantations performed at our center between 2001 and 2005 were selected for the study. We compared intraoperative parameters together with 15 other clinical and socio-demographic recipient and donor variables among patients experiencing DGF (n = 58) versus those with immediate graft function (IGF; n = 97). All significant variables at P < .05 upon univariate analysis were entered into a multivariate logistic regression model to identify risk factors for DGF. RESULTS: CVP at awakening of ≤8 mm Hg (odds ratio [OR] = 3.53; 95% confidence interval [CI], 1.63-7.63), fluid input during surgery ≤2.250 mL (OR = 2.12; 95% CI, 1.00-4.51), and recipient age ≥50 years (OR = 2.72; 95% CI, 1.11-6.68) were the strongest correlates of DGF. CONCLUSIONS: Our data suggested that reduced intraoperative perfusion as measured using CVP monitoring might increase DGF risk. This study provides the rationale to further investigate the optimal CVP target during this surgery. |
| File Format | HTM / HTML |
| ISSN | 00411345 |
| Issue Number | 9 |
| Volume Number | 42 |
| e-ISSN | 18732623 |
| Journal | Transplantation Proceedings |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Transplantation__semicolon__medicine Blood Pressure Determination Central Venous Pressure Delayed Graft Function Etiology Kidney Failure, Chronic Surgery Kidney Transplantation Adverse Effects Monitoring, Intraoperative Methods Adult Case-control Studies Physiopathology Female Humans Isotonic Solutions Administration & Dosage Italy Logistic Models Male Middle Aged Odds Ratio Plasma Substitutes Retrospective Studies Risk Assessment Risk Factors Treatment Outcome Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation Surgery |
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