NDLI: Preconditioning with gabexate is superior to inosine for ameliorating acute renal ischemia-reperfusion injury in rats.

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Preconditioning with gabexate is superior to inosine for ameliorating acute renal ischemia-reperfusion injury in rats.

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Preconditioning with gabexate is superior to inosine for ameliorating acute renal ischemia-reperfusion injury in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xie, L-B Zeng, D-Y Wang, X-D Lin, T. Li, Y-P Lu, Y-P
Description	Author Affiliation: Xie LB ( Department of Urology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, People's Republic of China.); Zeng DY ( Department of Urology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, People's Republic of China.); Wang XD ( Department of Urology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, People's Republic of China.); Lin T ( Department of Urology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, People's Republic of China.); Li YP ( Department of Urology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, People's Republic of China.); Lu YP ( Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, People's Republic of China. Electronic address: yipinglu@163.com.)
Abstract	OBJECTIVE: The objective of this study was to compare the protease inhibitor gabexate with widely used inosine for reducing renal ischemia-reperfusion injury. METHOD: A total of 48 rats were divided into 4 groups of 12 and administered gabexate, inosine, normal saline (NS), or nothing by injection through the vena dorsalis of the penis. Then all rats were subjected to right nephrectomy and 30-minute warm ischemia of the left kidney. At 24 and 48 hours after reperfusion, blood samples were collected from the inferior vena cava and serum creatinine (SCr) was assayed. Left kidney tissue was homogenized and used to assay malondialdehyde (MDA) and superoxide dismutase (SOD). The tissue was also analyzed using hematoxylin-eosin (HE) staining, TUNEL staining, and NF-κB immunohistochemistry. RESULTS: SCr level decreased after reperfusion more in the gabexate group than in the other groups. Reperfused kidney tissue in the gabexate group showed lower MDA levels but higher SOD activity than did tissue in the inosine and saline groups, as well as lower pathology scores based on HE staining, lower necrosis index, and lower levels of NF-κB expression (all P < .05). Tissue in the inosine and saline groups showed similar necrosis index and NF-κB expression (P > .05). CONCLUSION: Preconditioning with gabexate is superior to preconditioning with inosine for ameliorating rat renal ischemia-reperfusion injury. Future studies are needed to verify the effects of gabexate in the clinic, especially for kidney transplantation.
File Format	HTM / HTML
ISSN	00411345
Issue Number	1
Volume Number	46
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2014-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Acute Kidney Injury Drug Therapy Gabexate Therapeutic Use Inosine Ischemic Preconditioning Methods Protease Inhibitors Reperfusion Injury Animals Creatinine Blood Immunohistochemistry In Situ Nick-end Labeling Kidney Drug Effects Kidney Transplantation Male Malondialdehyde Metabolism Nf-kappa B Rats Rats, Sprague-dawley Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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