NDLI: The value of tubular enzymes for early detection of acute kidney injury after liver transplantation: an observational study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Santos, C. Marcelino, P. Carvalho, T. Coelho, J. Bispo, M. Mourão, L. Perdigoto, R. Barroso, E.
Spatial Coverage	Portugal
Description	Country affiliation: Portugal Author Affiliation: Santos C ( Nephrology Department, Amato Lusitano Hospital, Castelo Branco, Portugal. santos9_cat@yahoo.com)
Abstract	Tubular enzymes (TE) are early markers of acute kidney injury (AKI), but their value for liver transplant (LT) recipients is unknown. We sought to evaluate the usefulness of TE to predict AKI after LT. We enrolled Thirty-nine adult patients without AKI who had been admitted to the Intensive Care Unit (ICU). AKI was diagnosed according to the Acute Kidney Injury Network criteria. Of these patients, 23 had received orthotopic LT and 16 controls had been admitted for other conditions. Urinary lactate dehydrogenase (LDH), alkaline phosphatase (AF) and Î³-glutamyl transpeptidase (Î³-GT) measured on days 1 and 3 of the ICU stay were normalized to urinary creatinine concentrations. AKI was diagnosed in 14 patients: 8 in the LT group and 6 in the control group. In the LT group, on the first day of the patients' stay in the ICU, urinary LDH (P = .032), AF (P = .022), and Î³-GT (P = .002) were significantly higher among those who developed AKI; these elevations preceded those of serum creatinine. In forward receiver-operating characteristic (ROC) plot analysis, the areas under the ROC curves were 0.8, 0.86, and 0.92 for LDH, AF, and Î³-GT, respectively. We concluded that TE determined early after LT are a helpful predictors of AKI.
File Format	HTM / HTML
ISSN	00411345
Issue Number	9
Volume Number	42
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2010-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Acute Kidney Injury Diagnosis Alkaline Phosphatase Urine Clinical Enzyme Tests Kidney Tubules Enzymology L-lactate Dehydrogenase Liver Transplantation Adverse Effects Gamma-glutamyltransferase Etiology Adult Aged Aged, 80 And Over Biological Markers Blood Case-control Studies Creatinine Early Diagnosis Female Humans Intensive Care Units Male Middle Aged Portugal Predictive Value Of Tests Roc Curve Time Factors Treatment Outcome Up-regulation Evaluation Studies Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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