NDLI: Factors influencing the concentration of cytokines during liver transplantation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Koh, H-J Ryu, K-H Cho, M-L Heo, Y-J Lee, J.
Spatial Coverage	Republic of Korea
Description	Country affiliation: South Korea Author Affiliation: Koh HJ ( Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.)
Abstract	Not only does the underlying disease that requires surgery constitute a significant stress to the human body, but also the surgery itself serves as a stressor. Cytokine secretion is activated in response to the surgical stress during liver transplantation. We examined 44 patients to compare cytokine levels, according to the underlying diseases causing liver failure (viral hepatitis vs alcoholic hepatitis), examining whether the values differed according to the model for end-stage liver disease (MELD) score [high (≥20) vs low (<20)]. Pro-inflammatory cytokines tumor necrosis factor (TNF)- , interleukin (IL)1ß, and IL-6 and anti-inflammatory cytokines IL-4 and IL-10 were quantified using sandwich enzyme- linked immunoassays at three times: (1) after inducing anesthesia, (2) 60 minutes after the start of the anhepatic period, and (3) 60 minutes after reperfusion. No difference in the level of any cytokine measured in our study was detected at any time point between the viral and the alcoholic hepatitis groups. Among the high MELD group, IL-1ß and IL-4 contents were higher than in the low MELD group at all time points (P < .05). IL-10 concentrations at time 1 and TNF- at time 2 were higher among the high MELD group (P < .05). In conclusion, the severity of the inflammatory and stress reactions expressed as cytokine concentrations did not differ according to the underlying liver disease, but did associate with the MELD score.
File Format	HTM / HTML
ISSN	00411345
Issue Number	9
Volume Number	42
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2010-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Cytokines Blood Hepatitis, Alcoholic Immunology Hepatitis, Viral, Human Inflammation Mediators Liver Failure Surgery Liver Transplantation Enzyme-linked Immunosorbent Assay Humans Interleukins Adverse Effects Living Donors Republic Of Korea Severity Of Illness Index Time Factors Treatment Outcome Tumor Necrosis Factor-alpha Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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