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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rong, G. Jing, L. Deng-Qing, L. Hong-Shan, Z. Shai-Hong, Z. Xin-Min, N. |
| Spatial Coverage | China |
| Description | Country affiliation: China Author Affiliation: Rong G ( Organ Transplantation Institute of The Third Xiangya Hospital, Central South University, Changsha, China.) |
| Abstract | The aims of this study were to investigate the influence of CYP3A5 and MDR1 genetic polymorphisms on tacrolimus pharmacokinetics in Chinese renal transplant recipients, so as to help rational administration in clinical practice. We calculated pharmacokinetic parameters of tacrolimus from blood concentrations in steady state at day 28. Polymerase chain reaction restriction fragment length polymorphisms were used for CYP3A5 and MDR1 analysis. The results showed that the dose-adjusted area under the concentration time curve (AUC(0-12)) and renal clearance showed a significant difference between CYP3A5*1 carriers and the CYP3A5*3/*3 genotype (P < .01). In the following study, a distinction was made between carriers of CYP3A5*1/ vs CYP3A5*3/*3 seeking to investigate the influence of the MDR13435T>C polymorphism on tacrolimus pharmacokinetics. MDR1 3435T>C polymorphism did not affect any tacrolimus pharmacokinetic parameter in either group. Renal transplant recipients who were CYP3A5*1 carriers required a higher dose of tacrolimus than CYP3A5*3/*3, indicating a significantly lower dose-adjusted AUC(0-12) of tacrolimus. In contrast, MDR1 3435T>C polymorphism was not an important factor in tacrolimus pharmacokinetics. Pharmacogenetic methods may be used prospectively to aid dose selection and individualize immunosuppressive therapy. |
| File Format | HTM / HTML |
| ISSN | 00411345 |
| Issue Number | 9 |
| Volume Number | 42 |
| e-ISSN | 18732623 |
| Journal | Transplantation Proceedings |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Transplantation__semicolon__medicine Asian Continental Ancestry Group Genetics Cytochrome P-450 Cyp3a Immunosuppressive Agents Pharmacokinetics Kidney Transplantation Ethnology P-glycoprotein Polymorphism, Single Nucleotide Tacrolimus Adult Chi-square Distribution China Metabolism Drug Dosage Calculations Drug Monitoring Drug Therapy, Combination Female Gene Frequency Genotype Humans Administration & Dosage Blood Male Middle Aged Mycophenolic Acid Analogs & Derivatives P-glycoproteins Phenotype Polymerase Chain Reaction Steroids Young Adult Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation Surgery |
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