NDLI: Beneficial effects of apple peel polyphenols on vascular endothelial dysfunction and liver injury in high choline-fed mice

Content Provider	Royal Society of Chemistry (RSC)
Author	Jia, Mengfan Ren, Daoyuan Nie, Yan Yang, Xingbin
Copyright Year	2017
Abstract	This study was designed to investigate the preventive effects of Red Fuji apple peel polyphenolic extract (APP) on vascular endothelial dysfunction and liver injury in mice fed a high choline diet. The mice were fed 3% dietary choline in drinking water for 8 weeks and displayed vascular dysfunction and liver damage (p < 0.01). The administration of APP at 600 and 900 mg per kg bw significantly elevated serum NO, HDL and 6-Keto-PGF1a levels and lowered serum TC, TG, LDL, ET-1 and TXB2 levels in the HC-fed mice. Besides, APP also caused the reduction of AST, ALT activities and MDA, CRP, TNF-α levels, and increased the hepatic GSH-Px and SOD activities of the HC-fed mice. Furthermore, the histopathology of the liver by conventional H&E and oil red O staining confirmed the liver steatosis induced by a choline diet and the hepatoprotective effect of APP. The experiment results indicated that the polyphenolic extract from apple peel might be regarded as a preventive and therapeutic product for the amelioration of HC diet-induced vascular dysfunction and hepatic injury.
Starting Page	1282
Ending Page	1292
Page Count	11
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	8
Issue Number	3
Journal	Food & Function
DOI	10.1039/c7fo00147a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	AST MDA CRP Red Fuji Fuji (apple) Endothelium Liver Choline High-density lipoprotein Low-density lipoprotein Thromboxane B2 Alanine transaminase Tumor necrosis factor alpha Histopathology Oil Red O Steatosis Hepatoprotection
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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