NDLI: Rats’ urinary metabolomes reveal the potential roles of functional foods and exercise in obesity management

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Food & Function Vol - 8 Issue - 2

Food & Function Vol - 8 Issue - 1

Food & Function Vol -7

Food & Function Vol -6

Food & Function Vol -5

Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Rats’ urinary metabolomes reveal the potential roles of functional foods and exercise in obesity management

Content Provider	Royal Society of Chemistry (RSC)
Author	Abdel-Hamid, A. Z. El-Sheikh, N. M. Metwally, N. S. Farag, Mohamed A. Ammar, N. M. Wessjohann, Ludger A. Kholeif, T. E.
Copyright Year	2017
Abstract	The complexity of the metabolic changes in obese individuals still presents a challenge for the understanding of obesity-related metabolic disruptions and for obesity management. In this study, a gas chromatography mass spectrometry (GC-MS) based metabolomics approach targeting urine metabolism has been applied to assess the potential roles of functional foods and exercise for obesity management in rats. Male albino rats diagnosed as obese via histopathology and biochemical assays were administered functional foods in common use for obesity management including pomegranate, grapefruit, and red cabbage juice extracts in parallel with swimming exercise. Urine samples were collected from these rats, and likewise from healthy control animals, for metabolite analysis using (GC-MS) coupled to multivariate data analysis. The results revealed a significant elevation in oxalate and phosphate levels in obese rat urine concurrent with lower lactate levels as compared to the control group. Furthermore, and to pinpoint the bioactive agents in the administered functional foods, ultra performance liquid chromatography (UPLC) coupled to high resolution time-of-flight mass spectrometry (TOF-MS) was employed for secondary metabolite profiling. The different phenolic classes found in the examined functional foods, viz. ellagitannins in pomegranate, flavanones in grapefruit and flavonols in red cabbage, are likely to mediate their anti-obesity effects. The results indicate that these functional foods and exercise were quite effective in reverting obesity-related metabolic disruptions back to normal status, as revealed by orthogonal partial least squares-discriminant analysis (OPLS-DA).
Starting Page	985
Ending Page	996
Page Count	12
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	8
Issue Number	3
Journal	Food & Function
DOI	10.1039/c6fo01753c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Obesity Gas chromatography Mass spectrometry Gas chromatography\u2013mass spectrometry Metabolomics Urine Metabolism Albinism Histopathology Pomegranate Grapefruit Red cabbage Metabolite Multivariate analysis Phosphate Lactic acid High-performance liquid chromatography Time-of-flight mass spectrometry Secondary metabolite Orthogonality
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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