NDLI: Flavonoids from sea buckthorn inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through the MAPK and NF-κB pathways

Content Provider	Royal Society of Chemistry (RSC)
Author	Han, Jianchun Liu, Danyi Wu, Xi Fan, Mingcheng Guan, Haining Jiang, Fan
Copyright Year	2017
Abstract	Sea buckthorn has long been used as a functional food to regulate cholesterol, relieve angina, and diminish inflammation. Flavonoids are one of the main active components in sea buckthorn. We investigated the effects of sea buckthorn flavonoid (SF) treatment on two pathways that mediate inflammation, the mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) pathways, to explore the anti-inflammatory activity of SFs in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The LPS-induced over-production of nitric oxide (NO) and prostaglandin E2 (PGE2) was inhibited by SFs through a mechanism related to the modulatory effects of the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) genes. Additionally, SFs downregulated the production and mRNA expression of pro-inflammatory cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β. Moreover, SFs inhibited the phosphorylation of the p38 and stress-activated protein kinase/jun amino-terminal kinase (SAPK/JNK) MAPK pathways, and they reduced the nuclear translocation of NF-κB to prevent its activation by blocking the phosphorylation and degradation of inhibitor protein of NF-κB α (IκB-α). Based on these findings, SFs may exert their inhibitory effects on inflammation by regulating the release of inflammatory mediators through the MAPK and NF-κB pathways. SFs highlight the potential benefits of using functional foods with anti-inflammatory actions to combat inflammatory diseases.
Starting Page	1313
Ending Page	1322
Page Count	10
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	8
Issue Number	3
Journal	Food & Function
DOI	10.1039/c6fo01873d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MAPK Hippophae Functional food Cholesterol Angina pectoris Inflammation Flavonoid Mitogen-activated protein kinase NF-κB Lipopolysaccharide Macrophage Nitric oxide Prostaglandin Nitric oxide synthase Cyclooxygenase Prostaglandin-endoperoxide synthase 2 Messenger RNA Tumor necrosis factor alpha Interleukin-1 family Phosphorylation P38 mitogen-activated protein kinases Protein kinase Kinase C-Jun N-terminal kinases Inhibitor protein
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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