NDLI: Effects of dietary glucocerebrosides from sea cucumber on the brain sphingolipid profiles of mouse models of Alzheimer's disease

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Effects of dietary glucocerebrosides from sea cucumber on the brain sphingolipid profiles of mouse models of Alzheimer's disease

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Food & Function Vol - 8 Issue - 2

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Effects of dietary glucocerebrosides from sea cucumber on the brain sphingolipid profiles of mouse models of Alzheimer's disease

Content Provider	Royal Society of Chemistry (RSC)
Author	Tang, Qingjuan Xu, Jie Wang, Yuming Xue, Changhu Lu, Ling Zhang, Hongwei Song, Yu Cong, Peixu
Copyright Year	2017
Abstract	Herein, we investigated the potential relationship between sphingolipids and Alzheimer's disease (AD) with special attention to the relationship between dietary sea cucumber glucocerebrosides (SCGs) and sphingolipid metabolism. We assessed animal behavior using the Morris water maze test, determined Aβ1-42 concentration in the hippocampus using ELISA, and assessed the sphingolipid profile of the hippocampus and the cortex in normal mice (SAMR1), AD mice (SAMP8), and AD mice (SAMP8) fed with SCG using liquid chromatography-triple quadrupole mass spectrometry. We found that the SAMP8 mice had impaired memory and an SCG diet significantly rescued spatial memory deficits in these mice. As expected, we found that the profiles of sphingolipid species and the levels of total cerebrosides (CBS), ceramides (Cer), and sulfatides (ST) were significantly different in both the hippocampus and the cortex between the three groups; moreover, there were significantly lower ST levels and higher Cer and CBS levels in these regions in the SAMP8 mice. In the AD-SCG group, Cer and ST levels were altered only in the hippocampus, in contrast to the AD group. The major molecular species ST (d18:1-C24:1) and Cer (d18:1/18:0) were especially different between those of the two groups. Unexpectedly, sphingolipid profiles, including the nonhydroxylated fatty acid-ST/hydroxylated fatty acid-ST, very long fatty acid-galactocerebroside/long fatty acid-galactocerebroside, nonhydroxylated fatty acid-galactocerebroside/hydroxylated fatty acid-galactocerebroside and galactocerebroside/glucocerebroside ratios, were affected by AD. Thus, the ST and Cer levels and the profiles of sphingolipid species in the AD-SCG group were significantly different compared to those of the AD model group. Therefore, SCG has potential ameliorative effects in AD, and exogenous sphingolipid intake may potentially influence sphingolipid metabolism in vivo.
Starting Page	1271
Ending Page	1281
Page Count	11
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	8
Issue Number	3
Journal	Food & Function
DOI	10.1039/c6fo01659f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	SCG CBS ST ELISA Sea cucumber Sphingolipid Metabolism Morris water navigation task Hippocampus Cerebral cortex Sydney Cricket Ground Quadrupole Mass spectrometry Memory Galactocerebroside Glucocerebroside
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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