NDLI: Hypoglycemic and hepatoprotective effects of d-<i>chiro</i>-inositol-enriched tartary buckwheat extract in high fructose-fed mice

Content Provider	Royal Society of Chemistry (RSC)
Author	Ren, Daoyuan Luo, Yiyang Hu, Yuanyuan Zhao, Yan Guo, Jianjun Yang, Xingbin
Copyright Year	2015
Abstract	This study was designed to investigate the protective effects of D-Chiro-Inositol (DCI) enriched tartary buckwheat extract (DTBE) against high fructose (HF) diet-induced hyperglycemia and liver injury in mice. HPLC analysis revealed that the content of DCI present in purified DTBE was 34.06%. Mice fed 20% fructose in drinking water for 8 weeks significantly displayed hyperglycemia, hyperinsulinemia, dyslipidemia, hepatic steatosis and oxidative stress (p < 0.01). Continuous administration of DTBE in HF-fed mice dose-dependently reduced the HF-induced elevation of body weight, serum glucose, insulin, total cholesterol (TC), total triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels, as well as serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), C-reactive protein (CRP) and lactate dehydrogenase (LDH) activities, while the HF-induced decline of serum high density lipoprotein-cholesterol (HDL-C) levels could be markedly elevated in the mice. Meanwhile, DTBE also dose-dependently increased the hepatic total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) activities, and decreased hepatic malonaldehyde (MDA) levels, relative to HF-treated mice. Histopathology of H&E and Oil Red O staining confirmed liver injury induced by a HF diet and the hepatoprotective effect of DTBE. These findings are the first to demonstrate that the intake of DTBE may be a feasible preventive or therapeutic strategy for HF diet-induced hyperglycemia, hepatic steatosis and oxidative injury.
Starting Page	3760
Ending Page	3769
Page Count	10
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	12
Journal	Food & Function
DOI	10.1039/c5fo00612k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	CRP LDH MDA 1D-chiro-Inositol Tartary Buckwheat Fructose Hydrofluoric acid Hyperglycemia Liver High-performance liquid chromatography Hyperinsulinemia Dyslipidemia Fatty liver Oxidative stress Glucose Insulin Cholesterol Triglyceride Lipoprotein Alanine transaminase Aspartate transaminase C-reactive protein Lactate dehydrogenase Superoxide dismutase Glutathione peroxidase Oil Red O Hepatoprotection
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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