NDLI: Wild bitter gourd protects against alcoholic fatty liver in mice by attenuating oxidative stress and inflammatory responses

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Wild bitter gourd protects against alcoholic fatty liver in mice by attenuating oxidative stress and inflammatory responses

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Food & Function Vol - 5 Issue - 4

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Wild bitter gourd protects against alcoholic fatty liver in mice by attenuating oxidative stress and inflammatory responses

Content Provider	Royal Society of Chemistry (RSC)
Author	Liu, Chun-Ting Huang, Ching-Jang Lu, Kuan-Hung Sheen, Lee-Yan Chyuan, Jong-Ho Tseng, Hui-Chun
Copyright Year	2014
Abstract	Bitter gourd (Momordica charantia L.) is a common vegetable grown widely in Asia that is used as a traditional medicine. The objective of this study was to investigate whether wild bitter gourd possessed protective effects against chronic alcohol-induced liver injury in mice. C57BL/6 mice were fed an alcohol-containing liquid diet for 4 weeks to induce alcoholic fatty liver. Meanwhile, mice were treated with ethanol extracts from four different wild bitter gourd cultivars: Hualien No. 1′, Hualien No. 2′, Hualien No. 3′ and Hualien No. 4′. The results indicated that the daily administration of 500 mg kg body weight−1 of a Hualien No. 3′ extract (H3E) or a Hualien No. 4′ extract (H4E) markedly reduced the steatotic alternation of liver histopathology. In addition, the activation of serum aminotransferases (AST and ALT) and the accumulation of hepatic TG content caused by alcohol were ameliorated. The hepatoprotective effects of H3E and H4E involved the enhancement of the antioxidant defence system (GSH, GPx, GRd, CAT and SOD), inhibition of lipid peroxidation (MDA) and reduction of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in the liver. Moreover, H3E and H4E supplementation suppressed the alcohol-induced elevation of CYP2E1, SREBP-1, FAS and ACC protein expression. These results demonstrated that ethanol extracts of Hualien No. 3′ and Hualien No. 4′ have beneficial effects against alcoholic fatty liver, in which they attenuate oxidative stress and inflammatory responses.
Starting Page	1027
Ending Page	1037
Page Count	11
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	5
Issue Number	5
Journal	Food & Function
DOI	10.1039/c3fo60449g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	AST MDA Asia Hualien Gourd Momordica charantia Liver Fatty liver Ethanol Histopathology Aspartate transaminase Alanine transaminase Hepatoprotection Antioxidant Lipid peroxidation Tumor necrosis factor alpha Interleukin 1 beta Interleukin 6 CYP2E1 Sterol regulatory element-binding protein 1 Fatty acid synthase Anterior cingulate cortex Protein Oxidative stress
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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