NDLI: Sea cucumber peptides exert anti-inflammatory activity through suppressing NF-κB and MAPK and inducing HO-1 in RAW264.7 macrophages

Content Provider	Royal Society of Chemistry (RSC)
Author	Cheng, Xue Liu, Xueling Gao, Dongxiao Jiang, Naiyi Li, Tiange Du, Min Mao, Xueying Song, Jiajia Ji, Xiaomin
Copyright Year	2016
Abstract	The anti-inflammatory effect of sea cucumber peptides (SCP) in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages was tested. SCP significantly reduced LPS-induced nitric oxide release by inhibiting the inducible nitric oxide synthase mRNA expression without affecting the cell viability. The mRNA expression of LPS-induced inflammatory cytokines including tumour necrosis factor-α, interleukin (IL)-1β and IL-6 was suppressed. SCP inhibited LPS-induced degradation of the inhibitor of κBα (IκBα) and nuclear transposition of NF-κB p65, resulting in decreased NF-κB transactivation. Moreover, SCP suppressed the LPS-induced phosphorylation of JNK, ERK and p38. In addition, the expression of heme oxygenase (HO)-1 in macrophages was up-regulated by SCP in a dose-dependent manner. The inhibition effect of SCP on the mRNA expression of LPS-induced inflammatory cytokines was partially reversed by co-treatment with a HO-1 inhibitor. The SCP with anti-inflammatory activity was made up of low-molecular-weight peptides rich in glycine, glutamic acid and aspartic acid. Collectively, these results demonstrate that SCP exerts anti-inflammatory function through inhibiting NF-κB and MAPK activation and inducing HO-1 expression in macrophages.
Starting Page	2773
Ending Page	2779
Page Count	7
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	6
Journal	Food & Function
DOI	10.1039/c5fo01622c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	SCP ERK Sea cucumber Lipopolysaccharide Macrophage Nitric oxide Nitric oxide synthase Messenger RNA Necrosis Interleukin 6 Enzyme inhibitor IκBα NF-κB Phosphorylation C-Jun N-terminal kinases Mitogen-activated protein kinase P38 mitogen-activated protein kinases Heme oxygenase HMOX1 Glycine Gastric acid
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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