NDLI: Toxicokinetics of Metals in Terrestrial Invertebrates: Making Things Straight with the One-Compartment Principle

Content Provider	PubMed Central
Author	Boris, Skip Bednarska, Agnieszka J. Laskowski, Ryszard
Editor	Langowski, Jörg
Copyright Year	2014
Abstract	In this analysis, we first performed a critical review of one-compartment models used to describe metal toxicokinetics in invertebrates and found mathematical or conceptual errors in almost all published studies. In some publications, the models used do not represent the exact solution of the underlying one-compartment differential equations; others use unrealistic assumptions about constant background metal concentration and/or zero metal concentration in uncontaminated medium. Herein we present exact solutions of two differential-equation models, one describing simple two-stage toxicokinetics (metal toxicokinetic follows the experimental phases: the uptake phase and the decontamination phase) and another that can be applied for more complex three-stage patterns (toxicokinetic pattern does not follow two phases determined by an experimenter). Using two case studies for carabids exposed via food, based on previously published data, we discuss and compare our models to those originally used to analyze the data. Our conclusion is that when metal toxicokinetic follows a one-compartment model, the exact solution of a set of differential equations should be used. The proposed models allow assimilation and elimination rates to change between toxicokinetic stages, and the three-stage model is flexible enough to fit patterns that are more complex than the classic two-stage model can handle.
Related Links	http://dx.doi.org/10.1371/journal.pone.0108740
Starting Page	108740
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-09-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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