NDLI: Excretion of Urinary Orosomucoid 1 Protein Is Elevated in Patients with Chronic Heart Failure

Content Provider	PubMed Central
Author	Hou, Li-na Li, Fei Zeng, Qing-chun Su, Liang Chen, Ping-an Xu, Zhi-hao Zhu, Din-ji Liu, Chang-hua Xu, Ding-li
Editor	Beltrami, Antonio Paolo
Copyright Year	2014
Abstract	Easily screening markers for early detection of chronic heart failure (CHF) are lacking. We identified twenty differently expressed proteins including orosomucoid 1(ORM1) in urine between patients with CHF and normal controls by proteomic methods. Bioinformatics analyses suggested ORM1 could be used for further analysis. After verification by western blotting, the urinary levels of ORM1 were quantified with enzyme-linked immunosorbent assay (ELISA) by correcting for creatinine expression. The ORM1-Cr was significantly elevated in CHF patients than normal controls (6498.83±4300.21 versus 2102.26±1069.24 ng/mg). Furthermore, a Spearman analysis indicated that the urinary ORM1 levels had a high positive correlation with the classification of CHF, and the multivariate analysis suggested that the urinary ORM1 content was associated with the plasma amino-terminal pro- brain natriuretic peptide (NT-proBNP) (OR: 2.106, 95% CI: 1.213–3.524, P = 0.002) and the New York Heart Association (NYHA) classification (OR: 3.019, 95% CI: 1.329–4.721, P<0.001). In addition, receiving operating curve (ROC) analyses suggested that an optimum cut-off value of 2484.98 ng/mg with 90.91% sensitivity and 85.48% specificity, respectively, could be used for the diagnosis of CHF. To sum up, our findings indicate that ORM1 could be a potential novel urinary biomarker for the early detection of CHF.
Related Links	http://dx.doi.org/10.1371/journal.pone.0107550
Starting Page	107550
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-09-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Increased Circulating Cathepsin K in Patients with Chronic Heart Failure

Elevated Plasma Soluble ST2 Is Associated with Heart Failure Symptoms and Outcome in Aortic Stenosis

Leukocyte Redistribution: Effects of Beta Blockers in Patients with Chronic Heart Failure

Urinary Triclosan is Associated with Elevated Body Mass Index in NHANES

Decrease in Urinary Creatinine Excretion in Early Stage Chronic Kidney Disease

The Prognostic Value of Plasma Galectin-3 in Chronic Heart Failure Patients Is Maintained when Treated with Mineralocorticoid Receptor Antagonists

Trefoil Factor 1 Excretion Is Increased in Early Stages of Chronic Kidney Disease

Multimarker Proteomic Profiling for the Prediction of Cardiovascular Mortality in Patients with Chronic Heart Failure

The Prognostic Value of Peak Cardiac Power Output in Chinese Patients with Chronic Heart Failure

Excretion of Urinary Orosomucoid 1 Protein Is Elevated in Patients with Chronic Heart Failure

Similar Documents

Increased Circulating Cathepsin K in Patients with Chronic Heart Failure

Elevated Plasma Soluble ST2 Is Associated with Heart Failure Symptoms and Outcome in Aortic Stenosis

Leukocyte Redistribution: Effects of Beta Blockers in Patients with Chronic Heart Failure

Urinary Triclosan is Associated with Elevated Body Mass Index in NHANES

Decrease in Urinary Creatinine Excretion in Early Stage Chronic Kidney Disease

The Prognostic Value of Plasma Galectin-3 in Chronic Heart Failure Patients Is Maintained when Treated with Mineralocorticoid Receptor Antagonists

Trefoil Factor 1 Excretion Is Increased in Early Stages of Chronic Kidney Disease

Multimarker Proteomic Profiling for the Prediction of Cardiovascular Mortality in Patients with Chronic Heart Failure

The Prognostic Value of Peak Cardiac Power Output in Chinese Patients with Chronic Heart Failure

Excretion of Urinary Orosomucoid 1 Protein Is Elevated in Patients with Chronic Heart Failure