NDLI: Dual Immune Modulatory Effect of Vitamin A in Human Visceral Leishmaniasis

Content Provider	PubMed Central
Author	Maciel, Bruna L. Lima Valverde, Joanna Gardel Firmino, Rodrigues-neto João Francisco, Freire-neto Keesen, Tatjana S. L. Jeronimo, Selma Maria Bezerra
Editor	Piccirillo, Ciriaco A.
Copyright Year	2014
Abstract	Vitamin A supplementation has shown to prevent mortality by diarrheal and respiratory diseases in several countries. Nevertheless, there are few studies investigating the effect of vitamin A in visceral leishmaniasis (VL), although there are reports of its deficiency in children with symptomatic VL in Brazil and Bangladesh. This study analyzed the effect of vitamin A on a subset of Treg cells and monocytes isolated from symptomatic VL and from healthy children residing in an endemic area for VL in Northeast Brazil. Serum retinol concentrations correlated inversely with IL-10 and TGF-β productions in CD4+CD25highFoxp3+ T cells isolated from children with VL stimulated with leishmanial antigens. All-trans retinoic acid in vitro induced IL-10 in CD4+CD25highFoxp3+ T cells; IL-10 and TGF-β production in CD4+CD25−Foxp3− T cells, and IL-10 in monocytes isolated from healthy children. However, the use of all-trans retinoic acid together with leishmanial antigens in vitro prevented increases in IL-10 production in Treg cells and monocytes isolated from VL children. Strikingly, those results show a potential dual role of vitamin A in the immune system: improvement of a regulatory profile in cells from healthy children after leishmanial stimulation and down modulation of IL-10 in Treg cells and monocytes during symptomatic VL. Therefore, the use of vitamin A concomitant to VL therapy might be useful in improving recovery from disease status caused by Leishmania infantum infection and warrants additional study.
Related Links	http://dx.doi.org/10.1371/journal.pone.0107564
Starting Page	107564
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-09-30
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Correction: Dual Immune Modulatory Effect of Vitamin A in Human Visceral Leishmaniasis

Immune Suppression in Human in Visceral Leishmaniasis VL

Protein Malnutrition Impairs the Immune Response and Influences the Severity of Infection in a Hamster Model of Chronic Visceral Leishmaniasis

Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes

Immunoblot analysis of the humoral immune response to Leishmania donovani infantum polypeptides in human visceral leishmaniasis.

Dichotomy of protective cellular immune responses to human visceral leishmaniasis

Polyclonal B cell activation, circulating immune complexes and autoimmunity in human american visceral leishmaniasis.

A study of inflammation and immune regulation in blood and spleen during human visceral leishmaniasis

Evaluation of Ex Vivo Human Immune Response against Candidate Antigens for a Visceral Leishmaniasis Vaccine

Dual Immune Modulatory Effect of Vitamin A in Human Visceral Leishmaniasis

Similar Documents

Correction: Dual Immune Modulatory Effect of Vitamin A in Human Visceral Leishmaniasis

Immune Suppression in Human in Visceral Leishmaniasis VL

Protein Malnutrition Impairs the Immune Response and Influences the Severity of Infection in a Hamster Model of Chronic Visceral Leishmaniasis

Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes

Immunoblot analysis of the humoral immune response to Leishmania donovani infantum polypeptides in human visceral leishmaniasis.

Dichotomy of protective cellular immune responses to human visceral leishmaniasis

Polyclonal B cell activation, circulating immune complexes and autoimmunity in human american visceral leishmaniasis.

A study of inflammation and immune regulation in blood and spleen during human visceral leishmaniasis

Evaluation of Ex Vivo Human Immune Response against Candidate Antigens for a Visceral Leishmaniasis Vaccine

Dual Immune Modulatory Effect of Vitamin A in Human Visceral Leishmaniasis