NDLI: RGDechi-hCit: αvβ3 Selective Pro-Apoptotic Peptide as Potential Carrier for Drug Delivery into Melanoma Metastatic Cells

Content Provider	PubMed Central
Author	Capasso, Domenica Paola, Ivan De Liguoro, Annamaria Gatto, Annarita Del Gaetano, Sonia Di Guarnieri, Daniela Saviano, Michele Zaccaro, Laura
Editor	Ganesan, A.
Copyright Year	2014
Abstract	αvβ3 integrin is an important tumor marker widely expressed on the surface of cancer cells. Recently, we reported some biological features of RGDechi-hCit, an αvβ3 selective peptide antagonist. In the present work, we mainly investigated the pro-apoptotic activity of the molecule and its ability to penetrate the membrane of WM266 cells, human malignant melanoma cells expressing high levels of αvβ3 integrin. For the first time we demonstrated the pro-apoptotic effect and the ability of RGDechi-hCit to enter into cell overexpressing αvβ3 integrin mainly by clathrin- and caveolin-mediated endocytosis. Furthermore, we deepened and confirmed the selectivity, anti-adhesion, and anti-proliferative features of the peptide. Altogether these experiments give insight into the biological behavior of RGDechi-hCit and have important implications for the employment of the peptide as a new selective carrier to deliver drugs into the cell and as a therapeutic and diagnostic tool for metastatic melanoma. Moreover, since the peptide shows a pro-apoptotic effect, a great perspective could be the development of a new class of selective systems containing RGDechi-hCit and pro-apoptotic molecules or other therapeutic agents to attain a synergic action.
Related Links	http://dx.doi.org/10.1371/journal.pone.0106441
Starting Page	106441
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-09-23
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

High-density lipoprotein as a potential carrier for delivery of a lipophilic antitumoral drug into hepatoma cells

Multimeric RGD-Based Strategies for Selective Drug Delivery to Tumor Tissues

Tumor-selective peptide-carrier delivery of Paclitaxel increases in vivo activity of the drug

A Gene Expression Signature of Invasive Potential in Metastatic Melanoma Cells

Nano chitosan peptide as a potential therapeutic carrier for retinal delivery to treat age-related macular degeneration

Selective DNA Delivery to Tumor Cells Using an Oligoarginine-LTVSPWY Peptide

Prostaglandin D2 formation by malignant melanoma cells correlates inversely with cellular metastatic potential.

Marinopyrrole Derivatives with Sulfide Spacers as Selective Disruptors of Mcl-1 Binding to Pro-Apoptotic Protein Bim

Zinc Oxide Nanoparticles for Selective Destruction of Tumor Cells and Potential for Drug Delivery Applications

RGDechi-hCit: αvβ3 Selective Pro-Apoptotic Peptide as Potential Carrier for Drug Delivery into Melanoma Metastatic Cells

Similar Documents

High-density lipoprotein as a potential carrier for delivery of a lipophilic antitumoral drug into hepatoma cells

Multimeric RGD-Based Strategies for Selective Drug Delivery to Tumor Tissues

Tumor-selective peptide-carrier delivery of Paclitaxel increases in vivo activity of the drug

A Gene Expression Signature of Invasive Potential in Metastatic Melanoma Cells

Nano chitosan peptide as a potential therapeutic carrier for retinal delivery to treat age-related macular degeneration

Selective DNA Delivery to Tumor Cells Using an Oligoarginine-LTVSPWY Peptide

Prostaglandin D2 formation by malignant melanoma cells correlates inversely with cellular metastatic potential.

Marinopyrrole Derivatives with Sulfide Spacers as Selective Disruptors of Mcl-1 Binding to Pro-Apoptotic Protein Bim

Zinc Oxide Nanoparticles for Selective Destruction of Tumor Cells and Potential for Drug Delivery Applications

RGDechi-hCit: αvβ3 Selective Pro-Apoptotic Peptide as Potential Carrier for Drug Delivery into Melanoma Metastatic Cells