NDLI: Controlled induction of mechanical bioeffects with pulsed ultrasound and chemical agents

Content Provider	IEEE Xplore Digital Library
Author	Kawabata, K.-I. Maruoka, T. Asami, R. Ashida, R.
Copyright Year	2013
Description	Author affiliation: Osaka Med. Center for Cancer & Cardiovascular Diseases, Osaka, Japan (Ashida, R.) \|\| Central Res. Lab., Hitachi. Ltd., Tokyo, Japan (Kawabata, K.-I.; Maruoka, T.; Asami, R.)
Abstract	We aim to develop a novel low-invasive and effective treatment method of pancreatic tumor with synergistic effects of ultrasound and locally injected chemical agents such as anti-tumor drugs. In the treatment, controlling the spatial and temporal distribution of the agents by mechanical effects of ultrasound (cavitation) is a key process. To apply the mechanical effects to pancreases, a deep-seated organ, sensitizers for reducing the required acoustic intensity are essential. As preliminary experiments, we evaluated a formulation of superheated perfluorocarbon droplet, phase change nano droplet (PCND) as such a sensitizer. Effects on destruction of tissue structures were investigated ex vivo. It was found that ultrasound pulses with intensity higher than 2.2 $kW/cm^{2}$ was enough to induce mechanical effects of ultrasound in chicken breast tissues in the presence of PCND while no damages were observed in the absence of PCND. Increasing pulse intensity or PCND concentration increased destructed volume. It was found that pulse duration should be longer than 100 cycles and increasing duration more than 300 cycles does not increase the destructed volume significantly. Results obtained suggested that PCND works as a sensitizer for inducing mechanical effects in tissues.
Sponsorship	IEEE Ultrason., Ferroelectr., Freq. Control Society
Starting Page	2106
Ending Page	2109
File Size	843290
Page Count	4
File Format	PDF
ISSN	19485719
e-ISBN	9781467356862
DOI	10.1109/ULTSYM.2013.0538
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-21
Publisher Place	Czech Republic
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Tumors Drugs Acoustics Transducers Medical diagnostic imaging Joints tissue-structure destruction phase-change nano droplet mechanical effects cavitation
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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