NDLI: Transcranial ultrasound neuromodulation of the contralateral visual field in awake monkey

Content Provider	IEEE Xplore Digital Library
Author	Deffieux, T. Younan, Y. Tanter, M. Aubry, J.-F. Wattiez, N. Pouget, P.
Copyright Year	2013
Description	Author affiliation: Insitute of Brain & Spinal Cord, Paris, France (Wattiez, N.; Pouget, P.) \|\| Inst.-Langevin, ESPCI-ParisTech, Paris, France (Deffieux, T.; Younan, Y.; Tanter, M.; Aubry, J.-F.)
Abstract	In this work, we investigated the effect of low intensity pulsed focused ultrasound in the brain of two awake Maccaca Mulatta monkeys using the antisaccade (AS) paradigm. The objective of the study was to determine if transcranial ultrasound has an effect on behavioural tasks in awake animal involving a specific brain structure. Two Maccaca Mulatta monkeys (Y and L) were trained to perform antisaccade (AS) movements where they initially have to fix a central stimulus on a screen and then refrain from looking at an appearing peripheral target but instead initiate as soon as possible a saccade towards the opposite direction. In order to investigate the effect of low intensity focused ultrasound, a continuous 100 ms sonication pulse (derated pressure estimated at 0.35 ± 0.05 MPa) was focused at the frontal eye field using a 320 kHz transducer (H115, Sonic Concept, Bothell, WA, USA). Ipsilateral mean AS latencies with ultrasound stimulation were significantly (t-test;monkey Y: p=.0345, monkey L: p= .0311) increased compared to the non-stimulation condition (monkey Y: +14ms; monkey L: +15 ms). The study demonstrates the feasibility of using focused ultrasound to causally modulate behaviour in awake non-human primate brain.
Sponsorship	IEEE Ultrason., Ferroelectr., Freq. Control Society
Starting Page	1
Ending Page	4
File Size	139942
Page Count	4
File Format	PDF
ISSN	19485719
e-ISBN	9781467356862
DOI	10.1109/ULTSYM.2013.0001
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-21
Publisher Place	Czech Republic
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Acoustics Animals Transducers Neurosurgery Visualization Magnetic resonance imaging visual task brain neurostimulation non human primates neuromodulation
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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