NDLI: Production approaches for microbubbles loaded with nanoparticles

Content Provider	IEEE Xplore Digital Library
Author	Gauthier, M. Qian Yin Jianjun Cheng O'Brien, W.D.
Copyright Year	2013
Description	Author affiliation: Univ. of Illinois at Urbana-Champaign, Urbana, IL, USA (Gauthier, M.; Qian Yin; Jianjun Cheng; O'Brien, W.D.)
Abstract	A new production approach to make microbubbles (MBs) loaded with nanoparticles (NPs) (Protocol 1) was evaluated and compared with the more common procedure that was based on covalent linking of functionalized NPs (f-NPs) to MBs (Protocol 2). MBs were produced by sonicating bovine serum albumin (BSA) and dextrose solution. NPs consisted of Cy5-PLA conjugate. Protocol 1 involved incorporating the NPs into the BSA-dextrose solution before the sonication step. Protocol 2 involved mixing MBs and f-NPs, resulting from mixing the initial Cy5-PLA and PLA-PEG-COOH conjugates. For each protocol, unloaded MBs were produced as a reference. Two parameters were quantitatively analyzed using both analysis of variance (ANOVA) and t-test: diameter was estimated using a circle detection routine based on the Hough transform while the number density was estimated using a hemocytometer. Both parameters were evaluated for the NP-loaded MBs and unloaded MBs at 5 time points (2 hours to 5 days post MB fabrication). Protocols 1 and 2 resulted in significantly different loaded MBs: the more common approach of linking functionalized NPs to the MB surface (Protocol 2) was much more efficient than directly embedding NPs in the MB shell.
Sponsorship	IEEE Ultrason., Ferroelectr., Freq. Control Society
Starting Page	1521
Ending Page	1524
File Size	127493
Page Count	4
File Format	PDF
ISSN	19485719
e-ISBN	9781467356862
DOI	10.1109/ULTSYM.2013.0386
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-21
Publisher Place	Czech Republic
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Protocols Joining processes Ultrasonic imaging Nanoparticles Analysis of variance Loading Temporal stability Microbubbles Functionalized nanoparticles
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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