NDLI: A novel impedimetric immunosensor based on sol-gel derived Barium Strontium Titanate composite filnm

Content Provider	IEEE Xplore Digital Library
Author	Sun Lingling Tan Ooi Kiang Mao Baowei Tan Lay Im Gan Leong Huat Gan Yik Yuen
Copyright Year	2006
Description	Author affiliation: Nanyang Technol. Univ., Singapore (Sun Lingling; Tan Ooi Kiang; Mao Baowei; Tan Lay Im; Gan Leong Huat; Gan Yik Yuen)
Abstract	We report the development of a novel impedimetric immunosensor based on sol-gel derived barium strontium titanate (BST) composite film. On a platinum electrode, a layer of rough and porous BST composite film is deposited using sol-gel technique. A gold electrode is placed in parallel to the Pt electrode with a separating distance of 1 mm. 10 muL Dl water is applied between the two electrodes as contact media. On the BST grain surface, water molecules dissociate into H+ and OH", which contribute to the charge transfer between the two electrodes when an electrical field is applied. When bovine serum albumin (BSA) and anti-BSA molecules are immobilized onto the BST film surface, significant impedance increment between two electrodes is observed. This impedance increment is attributed to two factors. One, the BSA and anti-BSA molecules that immobilized on the BST surface prevent the water molecules from contacting the BST grains and induce less water molecules to dissociate into mobile ions. Two, the immobilized BSA and anti-BSA molecules act as obstacle barriers to the electron transfer between the solid/liquid interfaces. Comparing to the conventional electrochemical immunosensor, our present sensor is promising with higher sensitivity. Good linear relationship between impedance change and logarithm of anti-BSA concentration in a wide range is obtained.
Starting Page	482
Ending Page	485
File Size	1587833
Page Count	4
File Format	PDF
ISBN	1424403758
ISSN	19300395
DOI	10.1109/ICSENS.2007.355511
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-22
Publisher Place	South Korea
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Barium Strontium Titanium compounds Binary search trees Electrodes Surface impedance Platinum Gold Contacts Rough surfaces
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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