NDLI: Investigation of 4D PET attenuation correction using Ultra-short Echo Time MR

Content Provider	IEEE Xplore Digital Library
Author	Buerger, C. Aitken, A. Tsoumpas, C. King, A.P. Schulz, V. Marsden, P. Schaeffter, T.
Copyright Year	2011
Description	Author affiliation: Molecular Imaging Systems, Philips Research, Aachen, Germany (Schulz, V.) \|\| Division of Imaging Sciences and Biomedical Engineering, King's College, London, UK (Buerger, C.; Aitken, A.; Tsoumpas, C.; King, A.P.; Marsden, P.; Schaeffter, T.)
Abstract	In hybrid imaging systems where positron emission tomography (PET) is combined with magnetic resonance (MR) imaging, attenuation maps can be derived from MR to correct for attenuation in PET. However, MR-based attenuation correction (AC) remains challenging especially for tissue types showing poor signal in common MR sequences, such as bone. To overcome this problem, Ultra-short Echo Time (UTE) sequences have been proposed. Another challenge is given by respiratory motion which results in misalignments between the derived attenuation maps and the PET emissions. In this paper we address both issues. We compute a 4D attenuation map including bone from MR by combining a respiratory gated UTE acquisition with a subject-specific motion model derived from a second short dynamic acquisition. We demonstrate our approach on an MR-derived time-averaged PET simulation from three healthy volunteers, including three artificial lesions. The impact of bone on AC is simulated by excluding bone from the derived 4D map leading to errors of up to 26.0%. The impact of respiratory motion is simulated by using a non-moving 3D map, showing an error of up to 24.2%. These results indicate that a consideration of both bone tissue and respiratory motion is crucial to ensure accurate MR-based PET AC.
Starting Page	3558
Ending Page	3561
File Size	918045
Page Count	4
File Format	PDF
ISBN	9781467301183
ISSN	10823654
e-ISBN	9781467301206
DOI	10.1109/NSSMIC.2011.6153668
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-10-23
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Lead Biomedical imaging Positron emission tomography cortical bone MR PET simulation attenuation correction motion model ultrashort echo time
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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