NDLI: Using Monte-Carlo simulations to implement corrections for I-124 as a non-pure positron emitter in small animal and human PET imaging

Content Provider	IEEE Xplore Digital Library
Author	Sauerzapf, S. Thomas, L. Behe, M. Weber, W. Zakhnini, A. Pietrzyk, U. Mix, M.
Copyright Year	2011
Description	Author affiliation: University of Wuppertal, Dept. of Physics, 42097, Germany (Thomas, L.; Pietrzyk, U.) \|\| University Hospital Freiburg, Dept. of Nuclear Medicine, 79106, Germany (Sauerzapf, S.; Behe, M.; Weber, W.; Mix, M.)
Abstract	Using I-124 for PET imaging applications implies some difficulties concerning the image quality: The resolution is degraded by the large maximum positron energy of 2.1 MeV and the resultant long positron range. In addition I-124 is a non-pure PET isotope exhibiting additional gamma ray emissions with high contributions to the total decay scheme: 602.72 keV with 63% and 722.78 keV with 10%. These fractions cannot be quantified exactly in PET measurements. Therefore in our work we utilized GATE 6.1 [1] to investigate the effects of these supplementary “false” coincidences on a spectral, sinogram- and image-based basis. Three PET systems were modeled with GATE and confirming measurements were accomplished on them: Two small animal PET scanners (Raytest ClearPET and Concorde MicroPET Focus 120) and one human scanner (Philips Gemini TF 64). Derived from the simulated energy spectra, we propose narrower energy window configurations depending on the energy resolution of the different systems in order to minimize the amount of false coincidences. Separating the simulated sinograms for true and false coincidences revealed that a two-component correction for I-124 has to be implemented. A homogenous background subtraction is amended by a Gaussian-shaped fit with factors taken from GATE simulations which considers an additional portion of false coincidences within the phantom borders. Both methods, the energy windowing and the sinogram-based background correction, were successfully applied to measured data for different phantom geometries for the MicroPET scanner. Nevertheless comparative simulations of the MOBY mouse voxel phantom [2] with F-18 showed that the predominant effect in small animal imaging is the resolution loss due to the high positron range.
Starting Page	2688
Ending Page	2691
File Size	1218394
Page Count	4
File Format	PDF
ISBN	9781467301183
ISSN	10823654
e-ISBN	9781467301206
DOI	10.1109/NSSMIC.2011.6152950
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-10-23
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Logic gates Image resolution Energy resolution Positron emission tomography
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Implementation of Cascade Gamma and Positron Range Corrections for I-124 Small Animal PET

Characterization of a New MR Compatible Small Animal PET Scanner Using Monte-Carlo Simulations

Polar pixels for high resolution small animal PET

GATE Monte Carlo Simulation of a High-Sensitivity and High-Resolution LSO-Based Small Animal PET Camera

GATE Simulations of Human and Small Animal PET for Determination of Scatter Fraction as a Function of Object Size

Characterization of the short-lived non-pure positron emitter /sup 120/I for PET imaging

Simulation results of a small animal liquid xenon PET detector

Monte Carlo simulations studies in small animal PET using GATE

Iodine-124: A Promising Positron Emitter for Organic PET Chemistry

Using Monte-Carlo simulations to implement corrections for I-124 as a non-pure positron emitter in small animal and human PET imaging

Similar Documents

Implementation of Cascade Gamma and Positron Range Corrections for I-124 Small Animal PET

Characterization of a New MR Compatible Small Animal PET Scanner Using Monte-Carlo Simulations

Polar pixels for high resolution small animal PET

GATE Monte Carlo Simulation of a High-Sensitivity and High-Resolution LSO-Based Small Animal PET Camera

GATE Simulations of Human and Small Animal PET for Determination of Scatter Fraction as a Function of Object Size

Characterization of the short-lived non-pure positron emitter /sup 120/I for PET imaging

Simulation results of a small animal liquid xenon PET detector

Monte Carlo simulations studies in small animal PET using GATE

Iodine-124: A Promising Positron Emitter for Organic PET Chemistry

Using Monte-Carlo simulations to implement corrections for I-124 as a non-pure positron emitter in small animal and human PET imaging