NDLI: A direct time-of-flight reconstruction for whole-body single-bed RPC-PET: Results from lesion and anthropomorphic simulated data

Content Provider	IEEE Xplore Digital Library
Author	Martins, P. Blanco, A. Caramelo, F. Couceiro, M. Ferreira, N.C. Marques, R.F. Fonte, P. Mendes, L. Crespo, P.
Copyright Year	2011
Description	Author affiliation: LIP - Laboratório de Instrumentação e Física Experimental de Partículas, Physics Department, University of Coimbra, 3004-516, Portugal (Martins, P.; Blanco, A.; Couceiro, M.; Marques, R.F.; Fonte, P.; Crespo, P.) \|\| IBILI - Institute of Biomedical Research in Light and Image, Faculdade de Medicina da Universidade de Coimbra, 3000-548, Portugal (Caramelo, F.; Ferreira, N.C.; Mendes, L.)
Abstract	A single-bed, whole-body positron emission tomograph based on resistive plate chamber detectors has been proposed (RPC-PET). It has been shown by simulation that RPC-PET with an axial field-of-view (AFOV) of 2.4m is feasible and yields an absolute sensitivity enhancement of c. one order of magnitude superior to that of typical cylindrical, crystal-based PET scanners, with 16cm AFOV. In addition to its time-of-flight (TOF) advantage, RPC-PET offers potential very-high spatial resolution at the detector level. This must be properly handled by a fully-3D reconstruction algorithm capable of processing the very inclined lines-of-response (LOR) from large AFOV systems such as RPC-PET. For RPC-PET, these are acquired within a single-bed examination. Consequently, one or several segmented images representing the full human body during reconstruction are necessary. In this paper, we show that a direct-TOF implementation of the ordered subset expectation maximization (OSEM) algorithm allows for all events acquired with RPC-PET to be directly processed without rebinning and directly inserted inside the object image by means of a TOF-kernel. Such kernel (1) avoids typical (and slow) voxel-wise image navigation, (2) respects the time uncertainty dictated by the imaging RPC detectors, and (3) permits handling list-mode data iteratively with CT-based attenuation correction and OSEM computed both on-the-fly. We present reconstructed result from blind simulations of a single-bed, whole body PET system, corresponding to (1) six simulated spherical sources immersed in a homogeneous activity background, (2) an anthropomorphic phantom including a realistic grey-to-white matter uptake ratio of four, (3) and an additional anthropomorphic phantom with oncological lesions. We show that overall specificity for lesion detection may be increased (false positives decreased) by multiple similar, but independent reconstructions that eliminate false candidates arising from image statistical noise.
Starting Page	2610
Ending Page	2616
File Size	2880263
Page Count	7
File Format	PDF
ISBN	9781467301183
ISSN	10823654
e-ISBN	9781467301206
DOI	10.1109/NSSMIC.2011.6152701
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-10-23
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Image resolution Integrated circuits Phantoms Image segmentation
Content Type	Text
Resource Type	Article

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Whole-body single-bed time-of-flight RPC-PET: Simulation of axial and planar sensitivities with NEMA and anthropomorphic phantoms

Whole-Body Single-Bed Time-of-Flight RPC-PET: Simulation of Axial and Planar Sensitivities With NEMA and Anthropomorphic Phantoms

Comparison of list-mode and DIRECT approaches for time-of-flight PET reconstruction

Lesion segmentation in whole-body images of PET

Continuous bed motion acquisition on a whole body combined PET/CT system

Optimized weighting for Fourier rebinning of three-dimensional time-of-Flight PET data to non-time-of-flight

Measured spatially variant system response for PET image reconstruction

A comparison of breast lesion imaging capability of a whole-body PET camera and a brain/breast PET camera

Influence of Time-of-Flight Kernel Accuracy in TOF-PET Reconstruction

A direct time-of-flight reconstruction for whole-body single-bed RPC-PET: Results from lesion and anthropomorphic simulated data

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