NDLI: Complete Extension of Chromosomal DNA and Its Manipulation Using Optically-Driven Micro-Structures

Content Provider	IEEE Xplore Digital Library
Author	Terao, K. Kabata, H. Oana, H. Washizu, M.
Copyright Year	2006
Description	Author affiliation: Dept. of Mech. Eng., Tokyo Univ. (Terao, K.)
Abstract	This paper presents a novel method for extension and manipulation of chromosomal DNA using electroosmotic flow (EOF) and optically-driven micro-structures, which is intended for the use in nanotechnology-based genomic studies. Chromosomal DNA fibers are first hydrodynamically extended to the full length between micro-pillars on a substrate by EOF. In order to manipulate single chromosomal DNA fibers, we developed micro-hook and micro-bobbin, which were fabricated with SU-8 photo resist and grasped by focused laser beams. A targeted position of an extended DNA fiber was picked up with the micro-hook and translocated by moving the hook. To manipulate a whole DNA fiber, an extended fiber was wound to be compact using micro-bobbins. These handling techniques realize the observation of single chromosomal DNA molecules with high spatial resolution
Starting Page	1
Ending Page	5
File Size	481927
Page Count	5
File Format	PDF
ISBN	1424407176
DOI	10.1109/MHS.2006.320319
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-11-05
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biological cells DNA Image motion analysis Genomics Bioinformatics Resists Fiber lasers Laser beams Wounds Spatial resolution
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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