NDLI: The reconstruction of bioengineered organ by cell manipulation

Content Provider	IEEE Xplore Digital Library
Author	Nakao, K. Morita, R. Saji, Y. Ishida, K. Ogawa, M. Tomooka, Y. Tsuji, T.
Copyright Year	2006
Description	Author affiliation: Fac. of Ind. Sci. & Technol., Tokyo Univ. of Sci., Chiba (Nakao, K.; Morita, R.; Saji, Y.; Ishida, K.; Ogawa, M.; Tomooka, Y.; Tsuji, T.)
Abstract	It has been expected that technology for reconstitution of an entire organ from single cells for application to organ replacement strategies in regenerative therapy. In our current study, we show that the artificial organ germ, which generates a structurally correct organ, could be reconstituted by cell manipulation. Bioengineered tooth germ was reconstituted from epithelial and mesenchymal single cells, which were separated from E14.5 incisor tooth germ under stereoscopic microscope. Explants reconstituted with the compartmentalization between epithelial and mesenchymal cells at high-cell density could generate structurally correct teeth. Furthermore, individual primordia, which were dissected from the bioengineered tooth germ on day 2 of the organ culture, could generate a single tooth. These observations indicate that the initial cell density and the compartmentalization between cell types, which mimics epithelial mesenchymal cell interaction, are essential for the development of a bioengineered organ germ. Our results have a potential for the application of bioengineered organ in future regenerative therapies
Starting Page	1
Ending Page	4
File Size	4074807
Page Count	4
File Format	PDF
ISBN	1424407176
DOI	10.1109/MHS.2006.320294
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-11-05
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Teeth Animal structures Medical treatment Mice Biological materials Temperature Artificial biological organs Microscopy In vivo Guidelines
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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