NDLI: Disposition of arsenic in saliva, blood and urine of Sprague-Dawley rats following repeated oral exposure to sodium arsenite

Content Provider	IEEE Xplore Digital Library
Author	Dapeng Wang Liming Zhang Jian Li Jian Liu Xing Liu Huanyu Jin Chunyan Ji Chunling Fu Yan An
Copyright Year	2011
Description	Author affiliation: Department of Toxicology, School of Radiation Medicine & Public Health Medical College, Soochow University, Suzhou 215123, P.R. China (Dapeng Wang; Jian Liu; Xing Liu; Huanyu Jin; Chunyan Ji; Chunling Fu; Yan An) \|\| Suzhou Center For Disease Prevention And Control, Suzhou 215004, P.R. China (Liming Zhang; Jian Li)
Abstract	Biological monitoring for arsenic(As) was usually based upon a determination of urine and blood arsenic concentration, however, saliva had been suggested as a non-invasive biological matrix for assessing exposure. To further evaluated the potential utility of saliva for arsenic biomonitoring, Atomic Fluorescence Spectrometry(AFS-230) and Inductively Coupled Plasma Mass Spectrometer (ICP-MS) were used to evaluate the disposition of arsenic in whole blood, urine and saliva following repeated oral gavage doses of 0(control), 0.2, 2.0, 20.0 mg sodium arsenite/kg b.w. The results show that there is an obvious dose-response relationship of total arsenic concentration in blood, urine and saliva(P<0.05). Additionally, there is a significant positive association of salivary arsenic compared with blood arsenic (r=0.934, P<0.01) and urinary arsenic (r=0.960, P<0.01). These results demonstrate that the total arsenic in saliva had an obvious dose-response relationship, which can be used as a new biomarker for assessing human exposue to arsenic.
Starting Page	1156
Ending Page	1159
File Size	214251
Page Count	4
File Format	PDF
ISBN	9781612847238
e-ISBN	9781612847269
DOI	10.1109/HHBE.2011.6029031
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-19
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Urine Correlation Instruments Humans Rats Electron tubes Sodium arsenite Saliva Blood
Content Type	Text
Resource Type	Article

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