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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Li Ying Xu Lihua Zhan Ping Sun Miying Zhai Yujia Xu Lei Liu Tongku |
| Copyright Year | 2011 |
| Description | Author affiliation: Department of Cardiology, The Affiliated Hospital of Beihua University, Jilin, Jilin 132011, China (Li Ying; Xu Lihua; Zhan Ping; Sun Miying; Zhai Yujia; Xu Lei; Liu Tongku) |
| Abstract | To investigate the effects of NGF(Nerve Growth Factor) pretreatment on density of new vessels of acute myocardial infaction in rats. 60 male adult Wistar rats were randomly classified into three groups: the control (n=20), non-NGF (n=20) and NGF(n=20) groups. The NGF group was injected NGF (0.5μg/kg) via caudal vena. Then we performed left anterior descending coronary artery(LAD) ligation, all the rats were sacrificed at 7 days postsurgery. In this study we observe the morphologic changes of myocardial pathology and the serum biochemical changes in each group, including CK-MB, LDH and CnTI; To measure the expression of CD34, VEGF and KDR/flk-1 we use immunohistology and RT-PCR. Compared with the control group and the non-NGF group, the NGF group has a significant higher density of vessel(P<0.01). Our results indicated that NGF pretreatment can enhance the density of new vessels, promote the vasculogenesis and lessen the myocardial damage in rats. |
| Starting Page | 491 |
| Ending Page | 494 |
| File Size | 253815 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781612847238 |
| e-ISBN | 9781612847269 |
| DOI | 10.1109/HHBE.2011.6028039 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-08-19 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Heart Myocardial infarction Rat Myocardium Rats Software Vasculogenesis Nerve Growth Factor Injuries Arteries |
| Content Type | Text |
| Resource Type | Article |
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