NDLI: Sedative and hypnotic effects of Schisandra Chinensis baill lignans

Content Provider	IEEE Xplore Digital Library
Author	Jing Shu Shi Hui Wan Lihua Jiang Enping Chen Dongxue Chen Jianguang Fan Xintian
Copyright Year	2011
Description	Author affiliation: Pharmaceutical College, Beihua University, Jilin, China (Shi Hui; Wan Lihua; Jiang Enping; Chen Dongxue; Chen Jianguang; Fan Xintian) \|\| Affiliated Hospital, Beihua University, Jilin, China (Jing Shu)
Abstract	A multiple functional mice spontaneous activities recorder was applied to observe effects of SCL on mice spontaneous activities; Several classical methods were used to observe synergic hypnotic effects of SCL with pentobarbital sodium; Effects of SCL on GABA and Glu contents in brain tissue of mice were measured by using automatic microplate reader for ELISA to explore the mechanism. SCL could (1) reduce the number of in spontaneous activities in mice Significantly; (2) increase the number of sleep induced by pentobarbital sodium under the threshold sleep dosage in mice; (3) delay duration of sleep induced by pentobarbital sodium at the suprathreshold sleep dosage in mice, and shorten the latency of sleep; (4) reduce the content of Glu in the brain tissue of mice significantly. The results suggest that SCL could produce sedative and hypnotic effects on mice through reducing the Glu content in mice brain tissue.
Starting Page	514
Ending Page	517
File Size	201539
Page Count	4
File Format	PDF
ISBN	9781612847238
e-ISBN	9781612847269
DOI	10.1109/HHBE.2011.6028110
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-19
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Brain Sedative and hypnotic effects Neurotransmitters Schisandra Chinensis baill lignan (SCL) Central nervous system GABA Educational institutions Glutamate(Glu) Mice
Content Type	Text
Resource Type	Article

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