NDLI: The variation of NF-kB p65 and ICAM-1 induced by homocysteine in the brain microvascular endothelial cells (BMECs)

Content Provider	IEEE Xplore Digital Library
Author	Sun Wenping Liu Huimin
Copyright Year	2011
Description	Author affiliation: Department of Special Procurement Ward, The Affiliated Hospital of Beihua University, Jilin 132011, P.R. China (Sun Wenping; Liu Huimin)
Abstract	Purposes Through BMEC of cultured rats, the author studies the influence of Hcy on NF-kB p65 and its downstream regulatory factors ICAM-1 (intercellular adhesion molecule-1) after BMEC is injured. Methods Cultured BMVECs were under the intervention of both 1mmol/L Hcy and CuSO4 (4μmol/L) for 0 h, 6 h, 12 h, 18 h respectively in order to observe expressions of NF-kB p65 and ICAM-1 at different time points. Results After BMVECs were exposed to 1mmol/L Hcy, compared with 0h, the expression of ICAM-1 began to appear at 6h. The expression increased as the time was extended, with remarkable higher expression at12h (/7<0.05) and more much higher at18h(p<0.01). After the Hcy with the same density interfered in the BMEC, the nuclear transfer of NF-kB p65 increased remarkably (p<0.01) and then decreased gradually at 18h (p>0.05). Conclusions Hcy may lead to the nuclear transfer of NF-kB and induce the expression of ICAM-1.
Starting Page	402
Ending Page	405
File Size	242651
Page Count	4
File Format	PDF
ISBN	9781612847238
e-ISBN	9781612847269
DOI	10.1109/HHBE.2011.6027984
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-19
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Rabbits Brain microvascular endothelial cells Adhesives Atherosclerosis NF-kB Gray-scale Muscles Rats ICAM-1 Noise measurement Homocysteine
Content Type	Text
Resource Type	Article

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