NDLI: Clinical role of hWAPL in histologic diagnosis of cervical cancer and cervical intraepithelial neoplasia: Correlation with p16INK4a expression and HPV testing

Content Provider	IEEE Xplore Digital Library
Author	Yonghong Xie Guangtao Xu Peng Shen Xiaoyan Pan Linlong Chen Ruilin Yan Fumei Zhu Yanping Zhang
Copyright Year	2011
Description	Author affiliation: Department of Forensic Science, Jiaxing University Medical College, Jiaxing, P.R. China (Linlong Chen) \|\| Department of Pathology, Jiaxing University Medical College, Jiaxing, P.R. China (Yonghong Xie; Ruilin Yan; Fumei Zhu) \|\| Department of Gynecology, Haining Women's Hospital, Haining, P.R. China (Xiaoyan Pan) \|\| Department of Pathology, Haining Women's Hospital, Haining, P.R. China (Peng Shen) \|\| Department of Pathology, Jiaxing First Hospital, Jiaxing, P.R. China (Yanping Zhang) \|\| Department of General Surgery, Haining Women's Hospital, Haining, P.R. China (Guangtao Xu)
Abstract	In this study, we examined the expression of hWAPL in cervical intraepithelial neoplasia (CIN) I-III and cervical squamous cell carcinoma, and investigated clinical application value of hWAPL in diagnosis of cervical disease. 90 samples were collected, and two slides from each sample were immunostained using hWAPL and p16INK4a antibody. HPV-DNA testing was performed using the HC2 DNA test. The expression intensity of hWAPL in SCC group, CIN III group, CIN II group and CIN I group was obviously higher than that in normal cervix group, and the expression intensity in SCC group, CIN III group and CIN II group was higher than that in CIN I group. Based on ROC curves of hWAPL, when using ≥CIN I, ≥CIN II and ≥CIN III as cutoff for positive classification, area under the curve (AUC) was 0.815, 0.699, and 0.616, respectively. Therefore, hWAPL may be a promising candidate for diagnosis of low-grade CIN.
Starting Page	936
Ending Page	940
File Size	472041
Page Count	5
File Format	PDF
ISBN	9781612847238
e-ISBN	9781612847269
DOI	10.1109/HHBE.2011.6028977
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-19
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Immunohistochemistry Humans P16INK4a gene Educational institutions Human papilloma virus HWAPL gene Cervical cancer Neoplasms Immune system
Content Type	Text
Resource Type	Article

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