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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Zhao Dongming Yang Ping |
| Copyright Year | 2011 |
| Description | Author affiliation: Department of Cardiology, The Affiliated Hospital of Beihua University, Jilin City, China (Zhao Dongming) || Department of Cardiology, China-Japan Union Hospital of Jilin University, Chuangchun City, China (Yang Ping) |
| Abstract | Objectiv to study the anti-oxidation effects of atorvastatin and coenzyme Q10 on heart failure in rats. Methods: After ligating their left anterior descending coronary artery and feeding for 6 weeks, 24 survived rats were randomly divided into sham group (n=6), model group (n=6), atorvastatin group (n=6) and atorvastatin + coenzyme Q10 group (n=6). Following continuous intragastric administration for 5 weeks, hemodynamic parameters, heart weight/body weight (HW/BW), left ventricular heart weight/body weight (LVHW/BW), serum superoxide dismutase (SOD) activity and malondialdehyde (MDA) level were measured for rats. UCP2 mRNA expression levels were determined by RT-PCR in non-infarcted myocardium. Results: Atorvastatin combined with coenzyme Q10 can significantly increase ±dp/dtmax and SOD activity, and reduce left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), cardiac hypertrophy index, serum MDA levels and UCP2 mRNA expression levels (P<0.05∼0.001), but had no significant effect on heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) (P>0.05). Conclusion: Atorvastatin combined with coenzyme Q10 can down-regulate UCP2 mRNA expression levels in myocardial cells for rats with heart failure after myocardial infarction and improve energy metabolism in ventricular remodeling of heart failure via anti-oxidation effects. |
| Starting Page | 220 |
| Ending Page | 223 |
| File Size | 252907 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781612847238 |
| e-ISBN | 9781612847269 |
| DOI | 10.1109/HHBE.2011.6027938 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-08-19 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Heart Proteins Heart failure Coenzyme Q10 Uncoupling protein 2 (UCP2) Myocardium Rats Atorvastatin Blood Arteries |
| Content Type | Text |
| Resource Type | Article |
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