NDLI: Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes

Content Provider	IEEE Xplore Digital Library
Author	Jingqing Zhang Landry, M.P. Barone, P.W. Jong-Ho Kim Shangchao Lin Ulissi, Z.W. Dahua Lin Bin Mu Boghossian, A.A. Hilmer, A.J. Rwei, A. Hinckley, A.C. Shandell, M.A. Nair, N. Blake, S. Sen, F. Sen, S. Cray, R.G. Deyu Li Kyungsuk Yum Jin-Ho Ahn Hong Jin Heller, D.A. Essigmann, J.M. Blankschtein, D. Strano, M.S. Kruss, S.
Copyright Year	2014
Description	Author affiliation: Dept. of Chem. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA (Jingqing Zhang; Landry, M.P.; Barone, P.W.; Jong-Ho Kim; Shangchao Lin; Ulissi, Z.W.; Dahua Lin; Bin Mu; Boghossian, A.A.; Hilmer, A.J.; Rwei, A.; Hinckley, A.C.; Shandell, M.A.; Nair, N.; Blake, S.; Sen, F.; Sen, S.; Cray, R.G.; Deyu Li; Kyungsuk Yum; Jin-Ho Ahn; Hong Jin; Heller, D.A.; Essigmann, J.M.; Blankschtein, D.; Strano, M.S.; Kruss, S.)
Abstract	Nanomaterials are often functionalized with biological ligands to enable their use as sensors of biological activity. However, the intricacies of nano-bio interactions are poorly understood, which hampers our ability to design nanomaterial-based sensors. Current experimental tools have been unable to visualize interactions occurring on the nano-bio interface with the spatial and temporal resolution needed to quantify biological interactions at their fundamental length and time scales. To fill the need for concurrent visualization of nanoparticles and biomolecules, we have combined two common microscopy techniques, one being for the study of biomolecules and the other for the study of nanoparticles, into a single instrument that has the capacity to study both nanoparticles and biological molecules simultaneously with spatial and temporal resolution that is appropriate for nanoscale interactions. This novel instrument has been used for the characterization of high-sensitivity sensors by designing synthetic biological polymers to selectively encapsulate single-wall carbon nanotubes. The design of synthetic sensing tools based on nanoparticle-biomolecule hybrids is promising for areas in need of high-specificity sensors, such as label-free detection of molecules within a cell, nanoparticle-based diagnostic tools, and nanoscale therapeutics. We introduce three examples of high-sensitivity and high-selectivity synthetic sensors that have the ability to detect a variety of molecules on a single-molecule scale: riboflavin, L-thyroxine, and oestradiol. These sensors have been used to detect and quantify riboflavin levels within a live murine macrophage cell in real-time. The findings provided herein will enable the development of early-onset diagnostic tools at the level of a single cell.
Starting Page	1
Ending Page	2
File Size	3141573
Page Count	2
File Format	PDF
ISBN	9781479937288
DOI	10.1109/NEBEC.2014.6972997
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-04-25
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sensors Nanobioscience Fluorescence Plastics Nanoparticles Microscopy synthetic antibodies Carbon nanotubes sensors single-molecule imaging in vivo detection
Content Type	Text
Resource Type	Article

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