NDLI: Polymeric nanoparticles as immunomodulatory vaccine adjuvants for atherosclerosis

Content Provider	IEEE Xplore Digital Library
Author	Ahuja, S. Petersen, L.K. Moghe, P.V. Uhrich, K.
Copyright Year	2014
Description	Author affiliation: Dept. of Chem. & Chem. Biol., Rutgers Univ., Piscataway, NJ, USA (Uhrich, K.) \|\| Dept. of Biomed. Eng., Rutgers Univ., Piscataway, NJ, USA (Ahuja, S.; Petersen, L.K.; Moghe, P.V.)
Abstract	Atherosclerosis, defined as the buildup of lipid-rich plaques in arterial walls, is triggered by a low-level immune response to oxidized low-density lipoproteins (oxLDL). Current strategies target the hepatic synthesis of LDL and lack the ability to actually treat the cause of the disease, which is the body's response to the oxLDL. In this study, we have identifiied a new class of nanoparticle- (NP) based vaccine adjuvants capable of modulating the body's immune response. The degree of NP internalization and its effect on surface expression of several key markers in immune modulation, CD40, CD86, CD80, HLA-DR and HLA-DQ, were evaluated in primary human dendritic cells (DCs). The results suggest that $M_{12}PEG,$ $T^{L}_{12}PEG,$ $T^{D}_{12}PEG,$ and $T^{Meso}_{12}PEG$ were the most successful NP formulations at modulating a non-specific immune response (adjuvant capacity) in dendritic cells. These studies provide a promising strategy for the design and development of amphiphilic NP adjuvants for potential use as an atherosclerosis vaccine.
Starting Page	1
Ending Page	2
File Size	3218578
Page Count	2
File Format	PDF
ISBN	9781479937288
DOI	10.1109/NEBEC.2014.6972706
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-04-25
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Immune system Atherosclerosis Nanoparticles Vaccines Nanobioscience Polymers Educational institutions nanoparticles atherosclerosis vaccine adjuvant
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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