NDLI: Development of a cross flow filtration device for human blood cell fractionation

Content Provider	IEEE Xplore Digital Library
Author	Swargaloganathan, D.
Copyright Year	2014
Description	Author affiliation: Biomed. Eng. Dept., Rutgers The State Univ. of New Jersey, Piscataway, NJ, USA (Swargaloganathan, D.)
Abstract	Separation of non-homogenous cell mixture using microfluidic platforms is a widely researched subject area due to numerous applications in both cell biology research and clinical medicine diagnostics. Blood is a non-homogenous mixture composed of various types of cells, plasma, proteins etc. Centrifugation and membrane separations are widely used techniques to fractionate blood. However equipment used in the above methods may require varying degrees of technical training, are not necessarily sterile, can have contamination or leakage problems and are generally used to analyze large amount of blood (3-5 ml) in a batch process. The problem we are addressing in our research is producing a label free, low-cost and high throughput device that can fractionate whole blood sample and separate pathogens from blood cells as a therapeutic method for treating bacteremia (presence of bacteria in blood). As a preliminary step we fractionate blood cells based on size from the whole blood. This is accomplished via cross-flow filtration. The device is made of Polydimethylsiloxane (PDMS). Separation mechanism of the device uses different pore size membranes incorporated between each compartment as physical barriers to fractionate particles from the sample specimen so that the particles which are to pass through or are blocked from the next compartment are controlled and subpopulations are collected for further analysis. Eventual goal of this device is to remove pathogens and inflammatory proteins in the blood. This device can improve the efficiency of medical technology involved in hematological studies. Therefore modifications of this device can lead to new therapeutic equipment.
Starting Page	1
Ending Page	3
File Size	1935152
Page Count	3
File Format	PDF
ISBN	9781479937288
DOI	10.1109/NEBEC.2014.6972952
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-04-25
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Blood Biomembranes Plasmas Proteins Fluorescence Magnetic separation Dielectrophoresis photolithography microfluidics cell separation
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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