NDLI: Clinical administration of LPS endotoxin show changes in heart rate variability are detected prior to changes in temperature

Content Provider	IEEE Xplore Digital Library
Author	Demetrius, S. Griffel, B. Jan, B.U. Coyle, S.M. Macor, M.A. Reddell, M. Calvano, S.E. Semmlow, J.L. Corbett, S. Lowry, S.F.
Copyright Year	2014
Description	Author affiliation: Dept. of Biol., New Jersey City Univ., Jersey City, NJ, USA (Demetrius, S.) \|\| Dept. of Surg., Rutgers Univ., New Brunswick, NJ, USA (Griffel, B.; Jan, B.U.; Coyle, S.M.; Macor, M.A.; Reddell, M.; Calvano, S.E.; Semmlow, J.L.; Corbett, S.; Lowry, S.F.)
Abstract	Sepsis is a significant cause of hospital deaths, but early detection could save lives. Heart rate variability (HRV) is a measurement of the change in heart rate and may be useful as a marker for early detection of sepsis. In this study, E. coli endotoxin was administered to healthy human subjects and changes in temperature and HRV were monitored at 6 hours post administration. HRV features measured were pNN50 and multi-scale entropy (MSE). We modeled changes in baseline using a sigmoidal model with 3 variables to help quantify dynamics of HRV and temperature time series. Curves of HRV and temperature versus time demonstrated that changes in HRV features preceded changes in temperature. Our model fits indicate HRV changes both begin earlier and occur faster than temperature or heart rate. Our findings are consistent with other group findings that demonstrate changes in interbeat intervals can be detected earlier than other signs of systemic inflammation.
Starting Page	1
Ending Page	2
File Size	3219627
Page Count	2
File Format	PDF
ISBN	9781479937288
DOI	10.1109/NEBEC.2014.6972770
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-04-25
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Temperature measurement Heart rate variability Biomedical measurement Mathematical model Temperature sensors Educational institutions sepsis heart rate variability multi-scale entropy nonlinear signal analysis
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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