NDLI: Algorithm for pupillometric data analysis

Content Provider	IEEE Xplore Digital Library
Author	Canver, M.C. Canver, A.C. Revere, K.E. Amado, D. Bennett, J. Chung, D.C.
Copyright Year	2010
Description	Author affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 (Canver, M.C.) \|\| F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104 (Revere, K.E.; Amado, D.; Bennett, J.; Chung, D.C.) \|\| School of Biomedical Engineering, Drexel University College of Medicine, Philadelphia, PA 19104 (Canver, A.C.)
Abstract	Pupillometry is used clinically to evaluate retinal and optic nerve health by measuring pupillary function in response to light stimuli. We have developed an algorithm using murine pupillometric measurements to automate the analysis of pupillometric data. The raw data is filtered and thresholding is used to remove data caused by eye blinking, loss of pupil tracking, and/or head movement. Twelve physiologically relevant parameters are extracted from the collected data. Algorithm derived values do not deviate significantly from the manually calculated parameters (p ≥ 0.05). This algorithm can be used to establish normative values of pupillary light responses for humans, as well as wild-type and transgenic mouse strains, which can subsequently be used as reference metrics for characterizing the retinal phenotype of retinal disease. Furthermore, it will be instrumental in the assessment of functional visual recovery in humans and pre-clinical models of retinal degeneration and optic nerve disease following pharmacological or gene-based therapies.
Starting Page	1
Ending Page	2
File Size	185022
Page Count	2
File Format	PDF
ISBN	9781424468799
e-ISBN	9781424469246
DOI	10.1109/NEBC.2010.5458283
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-03-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Data analysis Retina Optical filters Humans Degenerative diseases Algorithm design and analysis Optical losses Tracking Data mining Mice
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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