NDLI: Micro-Computed Tomography analysis methods to assess sheep cancellous bone preservation

Content Provider	IEEE Xplore Digital Library
Author	Calton, E.F. Lukashova, L. Boskey, A.L.
Copyright Year	2010
Description	Author affiliation: City University of New York, Graduate Center Biomedical Engineering Department, City College Hospital for Special Surgery 535 E. 70th Street New York, NY 10021 (Calton, E.F.; Lukashova, L.; Boskey, A.L.)
Abstract	The goal of this study was to determine if mineral dissolution from cancellous bone specimens alters stereology parameters determined by Micro-Computed Tomography (Micro-CT). Sheep cancellous bone cores were excised from lumbar vertebrae and randomized for immediate storage in one of four “bathing” solutions — Phosphate Buffered Saline (PBS), PBS supersaturated with Hydroxyapatite (HA) (PBS+HA), PBS supplemented with Protease Inhibitor cocktail solution (PBS+PI), and Supersaturated HA PBS supplemented with Protease Inhibitor Cocktail (PBS+HA+PI). An additional sample was stored in 70% Ethanol (EtOH) to provide reference values since samples are often stored and processed by micro-CT in EtOH prior to mechanical tests. Common micro-CT parameters used to examine bone structure and quality can assess vertebral cancellous bone changes due to storage and handling. Micro-CT data were collected while the samples were stored in their storage and bathing solutions at baseline (t=0 months). Following data collection, samples were stored at −20°C for 6 months. Micro-CT data were re-collected and degradation effects on the cancellous bone specimens were evaluated in stereology parameters between samples stored in different solutions and for both time points. Specimen geometry and selected volumes used for data analysis were assessed for possible computational differences due to the software algorithms used for stereology. No differences were seen at baseline due to the specimen size or the pre-determined analysis volumes. Stereology differences were seen between bathing media groups at 6 months. Additionally, threshold values used for processing were different between the bathing solutions, reflecting changes due to solution density differences.
Starting Page	1
Ending Page	2
File Size	138463
Page Count	2
File Format	PDF
ISBN	9781424468799
e-ISBN	9781424469246
DOI	10.1109/NEBC.2010.5458148
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-03-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Tomography Cancellous bone Buffer storage Inhibitors Minerals Spine Ethanol Testing Degradation Computational geometry
Content Type	Text
Resource Type	Article

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